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Omega-3 fatty acid in pregnancy reduces risk of preterm and early preterm birth – Feb 2024


Omega-3 fatty acid supply in pregnancy for risk reduction of preterm and early preterm birth

Am J Obstet Gynecol MFM. 2024 Feb;6(2):101251. doi: 10.1016/j.ajogmf.2023.101251
Irene Cetin 1, Susan E Carlson 2, Christy Burden 3, Eduardo B da Fonseca 4, Gian Carlo di Renzo 5, Adamos Hadjipanayis 6, William S Harris 7, Kishore R Kumar 8, Sjurdur Frodi Olsen 9, Silke Mader 10, Fionnuala M McAuliffe 11, Beverly Muhlhausler 12, Emily Oken 13, Liona C Poon 14, Lucilla Poston 15, Usha Ramakrishnan 16, Charles C Roehr 17, Charles Savona-Ventura 18, Cornelius M Smuts 19, Alexandros Sotiriadis 20, Kuan-Pin Su 21, Rachel M Tribe 22, Gretchen Vannice 23, Berthold Koletzko 24; Clinical Practice Guideline on behalf of Asia Pacific Health Association (Pediatric-Neonatology Branch), Child Health Foundation (Stiftung Kindergesundheit), European Academy of Paediatrics, European Board & College of Obstetrics and Gynaecology, European Foundation for the Care of Newborn Infants, European Society for Paediatric Research, and International Society for Developmental Origins of Health and Disease

This clinical practice guideline on the supply of the omega-3 docosahexaenoic acid and eicosapentaenoic acid in pregnant women for risk reduction of preterm birth and early preterm birth was developed with support from several medical-scientific organizations, and is based on a review of the available strong evidence from randomized clinical trials and a formal consensus process.
We concluded the following.

  • Women of childbearing age should obtain a supply of at least 250 mg/d of docosahexaenoic+eicosapentaenoic acid from diet or supplements, and
  • in pregnancy an additional intake of ≥100 to 200 mg/d of docosahexaenoic acid.

Pregnant women with a low docosahexaenoic acid intake and/or low docosahexaenoic acid blood levels have an increased risk of preterm birth and early preterm birth. Thus, they should receive a supply of approximately 600 to 1000 mg/d of docosahexaenoic+eicosapentaenoic acid, or docosahexaenoic acid alone, given that this dosage showed significant reduction of preterm birth and early preterm birth in randomized controlled trials. This additional supply should preferably begin in the second trimester of pregnancy (not later than approximately 20 weeks' gestation) and continue until approximately 37 weeks' gestation or until childbirth if before 37 weeks' gestation. Identification of women with inadequate omega-3 supply is achievable by a set of standardized questions on intake. Docosahexaenoic acid measurement from blood is another option to identify women with low status, but further standardization of laboratory methods and appropriate cutoff values is needed. Information on how to achieve an appropriate intake of docosahexaenoic acid or docosahexaenoic+eicosapentaenoic acid for women of childbearing age and pregnant women should be provided to women and their partners.
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21591 O-3 pregnancy_CompressPdf.pdf admin 17 Aug, 2024 157.63 Kb 275