So Tell Me . . . What Are You Doing to Prevent Breast Cancer - June 2017

So Tell Me . . . What Are You Doing to Prevent Breast Cancer?

 You can also download his July 2017 PDF from VitaminDWiki

Blog Post by Eugene Heyden
"As a post-surgical recovery nurse, I see it almost every day in my nursing practice. I wish so many did not have to be so brave."
His published books include
Preventing Birth Defects: Understanding the Iodine/Thyroid Hormone Connection
More To Consider In The Battle Against Crohn's
The Impact of Vitamin D Deficiency
Mommy, Me and Vitamin D

He has a good overview of studies of Breast Cancer prevention/treatment by

• Vitamin D
• Iodine
• Iron
• Stop Smoking

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See also VitaminDWiki

• Iron deficiency is a cause of Vitamin D deficiency
• Vitamin D and Iodine are similar, and both are deficient and important to health
• Iodine deficiency
• Iodine category listing has 31 items helps a lot with pregnancy too
• Hypothesis: Premenopausal Iron deficiency causes increased recurrence of breast cancer – 2008
• 6X less Breast Cancer if have even minimal vitamin D – July 2013
• Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
• Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
  Note: Includes many low-cost ways to improve your Vitamin D Receptor
• Hypothesis: 7X increase in Iodine deficiency explains increased rate of breast cancer remote metastasis – Jan 2017

Overview Breast Cancer and Vitamin D contains the following summary and sections

• 25 Meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 259 items along with related searches
• Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
• Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
• Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
• Vitamin D both prevents and treats Breast Cancer – 2019

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His references

• Aceves C, Anguiano B, Delgado G 2005 Is Iodine a Gatekeeper of the Integrity of the Mammary Gland? Journal of Mammary Gland Biology and Neoplasia. Apr 1; 10(2):189–196
• Anguiano B, Aceves C 2011 Iodine in Mammary and Prostate Pathologies. Current Chemical Biology. Sep 1; 5(3):177–182
• Crew KD, Gammon MD, Steck SE, Hershman DL, Cremers S, Dworakowski E, Shane E, Terry MB, Desai M, Teitelbaum SL, Neugut AI 2009 Association Between Plasma 25-Hydroxyvitamin D and Breast Cancer Risk. Cancer Prevention Research. Jun 1; 2(6):598–604
• Cui Y, Rohan TE 2006 Vitamin D, Calcium, and Breast Cancer Risk: A Review. Cancer Epidemiol Biomarkers Prev 15(18):1427–1437
• Diallo A, Deschasaux M, Partula V, Latino-Martel P, Srour B, Hercberg S, Galan P, Fassier P, Guéraud F, Pierre FH, Touvier M 2016 Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation. Oncotarget. Oct 12; 7(48):79008–79016
• Gaudet MM, Gapstur SM, Sun J, Diver WR, Hannan LM, Thun MJ 2013 Active Smoking and Breast Cancer Risk: Original Cohort Data and Meta-Analysis. Journal of the National Cancer Institute. Feb 28: djt023
• Gerber B, Müller H, Reimer T, Krause A, Friese K 2003 Nutrition and Lifestyle Factors on the Risk of Developing Breast Cancer. Breast Cancer Research and Treatment. May 1; 79(2):265–276
• Holick MF, Chen TC 2008 Vitamin D Deficiency: A Worldwide Problem with Health Consequences. The American Journal of Clinical Nutrition. Apr 1; 87(4):1080S–1086S
• Jian J, Yang Q, Dai J, Eckard J, Axelrod D, Smith J, Huang X 2011 Effects of Iron Deficiency and Iron Overload on Angiogenesis and Oxidative Stress—A Potential Dual Role for Iron in Breast Cancer. Free Radical Biology and Medicine. Apr 1; 50(7):841–847
• Kitagishi Y, Kobayashi M, Matsuda S 2013 Defective DNA Repair Systems and the Development of Breast and Prostate Cancer (Review). International Journal of Oncology. Jan 1; 42(1):29–34
• Liehr JG, Jones J 2001 Role of Iron in Estrogen-Induced Cancer. Current Medicinal Chemistry. Jun 1; 8(7):839–49
• McDonnell SL, Baggerly C, French CB, Baggerly LL, Garland CF, Gorham ED, Lappe JM, Heaney RP 2016 Serum 25-Hydroxyvitamin D Concentrations ≥ 40 ng/mL Are Associated with > 65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study. PloS one. Apr 6; 11(4):e0152441
• Moore AB, Shannon J, Chen C, Lampe JW, Ray RM, Lewis SK, Lin M, Stalsberg H, Thomas DB 2009 Dietary and Stored Iron as Predictors of Breast Cancer Risk: A Nested Case-Control Study in Shanghai. International Journal of Cancer. Sep 1; 125(5):1110–1117
• Pearce EN, Anderson M, Zimmerman MB 2013 Global Iodine Nutrition: Where Do We Stand in 2013? Thyroid. 23(5):523–528
• Pierce BL, Ballard-Barbash R, Bernstein L, Baumgartner RN, Neuhouser ML, Wener MH, Baumgartner KB, Gilliland FD, Sorensen BE, McTiernan A, Ulrich CM 2009 Elevated Biomarkers of Inflammation Are Associated with Reduced Survival Among Breast Cancer Patients. Journal of Clinical Oncology. May 26; 27(21):3437–3444
• Rappaport J. 2017 Changes in Dietary Iodine Explains Increasing Incidence of Breast Cancer with Distant Involvement in Young Women. Journal of Cancer. 8(2):174–177   download PDF from VitaminDWiki
• Reynolds P, Hurley S, Goldberg DE, Anton-Culver H, Bernstein L, Deapen D, Horn-Ross PL, Peel D, Pinder R, Ross RK, West D 2004 Active Smoking, Household Passive Smoking, and Breast Cancer: Evidence from the California Teachers Study. Journal of the National Cancer Institute. Jan 7; 96(1):29–37
• Shao T, Klein P, Grossbard M 2012 Vitamin D and Breast Cancer. The Oncologist. Jan 1; 17(1):36–45
• Smyth PP 2003 The Thyroid, Iodine and Breast Cancer. Breast Cancer Research. Jul 29; 5(5):235–238
• Teng X, Shan Z, Chen Y, Lai Y, Yu J, Shan L, Bai X, et al 2011 More Than Adequate Iodine Intake May Increase Subclinical Hypothyroidism and Autoimmune Thyroiditis: A Cross-Sectional Study Based on Two Chinese Communities with Different Iodine Intake Levels. European Journal of Endocrinology 164:943–950