Needed more than 1600 IU of vitamin D during pregnancy – RCT May 2013

Vitamin D requirement in pregnancy to prevent deficiency in neonates: a randomised trial.

Singapore Med J. 2013 May;54(5):285-288.
Shakiba M, Iranmanesh MR.
Paediatric Department, Shahid Sadoughi Medical University, Avicenna St, Yazd, Iran. shakiba at ssu.ac.ir.

Introduction: The exact amount of vitamin D required for pregnant women to adequately supply the foetus during pregnancy is still unclear. This randomised trial attempted to determine the optimal dose of vitamin D necessary during pregnancy in order to attain a vitamin D level > 20 ng/mL in neonates.

Methods: A total of 51 healthy, pregnant women in Yazd, Iran, were recruited in 2009. Of these, 34 were randomised to receive either

• 50,000 IU (Group A ) or
• 100,000 IU (Group B ) of vitamin D3

per month from the second trimester of pregnancy.
The remaining 17 pregnant women, who formed the third group

• (Group C) and were found to have vitamin D deficiency, were initially treated with 200,000 IU of vitamin D3,
  following which the dose was adjusted to 50,000 IU per month.

25-hydroxyvitamin D (25[OH]D) in cord blood was measured by chemiluminescence immunoassay, and a serum 25(OH)D level < 20 ng/mL was defined as deficiency.

Results: All the pregnant women had a vitamin D level < 30 ng/mL at the beginning of the second trimester.
The neonates of 76% of women from Group A had sufficient levels of 25(OH)D.
All the neonates born to women in Groups B and C had 25(OH)D > 20 ng/mL.
No side effects were observed in our participants during the period of vitamin D supplementation.

Conclusion: A vitamin D3 dose > 50,000 IU/month is required during the second and third trimesters of pregnancy for vitamin D-deficient pregnant women in order for their neonates to achieve serum 25(OH)D levels > 20 ng/mL.
Supplementation with < 50,000 IU/month is insufficient to ensure a vitamin D level > 20 ng/mL in all neonates born to vitamin D-deficient pregnant women.

PMID: 23716156

Vitamin D levels needed

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See also VitaminDWiki

• Near the end of pregnancy 50,000 IU vitamin D weekly was great – RCT April 2013
• 35,000 IU vitamin D weekly during 3rd quarter pregnancy – RCT March 2013
• Optimal Vitamin D during pregnancy - 4000 IU March 2012
• Overview Pregnancy and vitamin D which has the following summary
  

  IU	Cumulative Benefit	Blood level	Cofactors	Calcium	$*/month
  200	Better bones for mom with 600 mg of Calcium	6 ng/ml increase	Not needed	No effect	$0.10
  400	Less Rickets (but not zero with 400 IU) 3X less adolescent Schizophrenia Fewer child seizures	20-30 ng/ml	Not needed	No effect	$0.20
  2000	2X More likely to get pregnant naturally/IVF 2X Fewer dental problems with pregnancy 8X less diabetes 4X fewer C-sections (>37 ng) 4X less preeclampsia (40 ng vs 10 ng) 5X less child asthma 2X fewer language problems age 5	42 ng/ml	Desirable	< 750 mg	$1
  4000	2X fewer pregnancy complications 2X fewer pre-term births	49 ng/ml	Should have cofactors	< 750 mg	$3
  6000	Probable: larger benefits for above items Just enough D for breastfed infant More maternal and infant weight		Should have cofactors	< 750 mg	$4

Short url =http://is.gd/neonate_vitD