Vitamin D receptor (VDR) gene polymorphism and osteoporosis risk in White British men
Annals of Human Biology, Pages 430-433 https://doi.org/10.1080/03014460.2019.1659851
Melissa Kow, Elizabeth Akam, Puneetpal Singh, Monica Singh, Nick Cox,Jasvinder Singh Bhatti
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor Activation can be increased by any of:
Resveratrol, Omega-3, Magnesium, Zinc, non-daily Vitamin D dosing, etc
Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Items in both categories Osteoporosis and VDR are listed here:
- Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018
- Genes that increase the risk of Osteoporosis: Vitamin D Receptor is number one in Asians– April 2022
- Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019
- Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019
- Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
- Osteoporosis is associated with more than vitamin D genes – Jan 2016
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
Items in both categories Bones and VDR are listed here:
- 100 years since the discovery of Vitamin D - 23 studies - 2022, 2023
- Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Adolescent idiopathic scoliosis 2 X more likely in Asians with poor Vitamin D Receptor
Overview Osteoporosis and vitamin D contains the following summary
- FACT: Bones need Calcium (this has been known for a very long time)
- FACT: Vitamin D improves Calcium bioavailability (3X ?)
- FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
- FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
- FACT: Vitamin D supplements are very low cost
- FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
- FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
- FACT: Co-factors help build bones.
- FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
- It appears that to TREAT Osteoporosis:
- Calcium OR vitamin D is ok
- Calcium + vitamin D is good
- Calcium + vitamin D + other co-factors is great
- Low-cost Vitamin D Receptor activators sometimes may be helpful
- CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
- Category Osteoporosis has
221 items - Category Bone Health has
314 items Note: Osteoporosis causes bones to become fragile and prone to fracture
Osteoarthritis is a disease where damage occurs to the joints at the end of the bones
In this study, VDR gene ApaI (rs7975232), BsmI (rs 1544410) and TaqI (rs731236) genotypes were compared in men with osteoporosis and male controls. Osteoporosis affects around 20% of all men and overall mortality in the first year after hip fracture is significantly higher in men than women, yet the genetic basis of osteoporosis is less well studied in males. This study consisted of White British males; 69 osteoporosis patients and 122 controls. BMDs at the lumbar spine (vertebrae L1–L4) and hip (femur neck) were measured by dual-energy X-ray absorptiometry (DEXA). The VDR gene ApaI, BsmI and TaqI genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and association analysis was carried out at genotype and haplotype level. Our study suggests that TaqI polymorphism CC genotype frequency is lower in controls and further analysis of genotypes and BMD revealed a significant effect of TaqI polymorphism on Lumbar spine BMD. Two haplotypes (GCC and AAT) were associated with increased osteoporosis risk. In conclusion, VDR gene TaqI polymorphism in recessive mode had a significant effect on lumbar spine BMD within our study. Haplotypes GCC and AAT increase the risk of osteoporosis among White British males.Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 20193617 visitors, last modified 01 Nov, 2019, This page is in the following categories (# of items in each category) - Category Bone Health has