Effect of monthly vitamin D on diverticular disease hospitalization: post-hoc analysis of a randomized controlled trial
Clinical Nutrition https://doi.org/10.1016/j.clnu.2020.08.030
Zhenqiang Wu ab JoannaBroadbJohnSluyteraDebbieWaayera Carlos A.Camargo Jr.c Robert Scragg a
Big increase in diverticular disease in the group not getting the monthly vitamin D
Background & aims
Some studies have linked low vitamin D status and high risk of diverticular disease, but the causal relationship between vitamin D and diverticular disease remains unclear; clinical trial data are warranted. The objective was to assess the efficacy of vitamin D3 supplementation on diverticular disease hospitalization.
Methods
Post-hoc analysis of a community-based randomized double-blind placebo-controlled trial (RCT) with 5108 participants randomized to receive monthly 100,000 IU vitamin D (n=2558) or identical placebo (n=2550). The outcome was time to first diverticular disease hospitalization from randomization to the end of intervention (July 2015), including a prespecified subgroup analysis in participants with baseline deseasonalized 25-hydroxyvitamin D (25(OH)D) levels <50 nmol/L.
Results
Over a median of 3.3 years follow-up, 74 participants had diverticular disease hospitalization. There was no difference in the risk of diverticular disease hospitalization between vitamin D supplementation (35/2558=1.4%) and placebo (39/2550=1.5%) groups (adjusted hazard ratio [HR]=0.90; p=0.65), although in participants with deseasonalized 25(OH)D <50 nmol/L (n=1272), the risk was significantly lower in the vitamin D group than placebo (HR=0.08, p=0.02).
Discussion
Monthly 100,000 IU vitamin D3 does not reduce the risk of diverticular disease hospitalization in the general population. Further RCTs are required to investigate the effect of vitamin D supplementation on the diverticular disease in participants with low 25(OH)D levels.
 Download the PDF from Sci-Hub via VitaminDWiki
See also web
- Higher Serum Levels of Vitamin D Are Associated With a Reduced Risk of Diverticulitis - Dec 2013
- Paradigm shift: the Copernican revolution in diverticular disease - Nov 2019
-  Download the PDF from VitaminDWiki
- Note: two of the risk factors (Smoking, obesity) are strongly associated with low vitamin D
RCT with 100,000 IU monthly
- Across all 2550 patients - not statistically significant
- For those 1272 who have Vitamin D levels 20ng - 12X improvement
Results would probably have been even better if used a gut-friendly form of Vitamin D
Overview Gut and vitamin D contains gut-friendly information
Getting Vitamin D into your body has the following chart
Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut
Bio | Form | Speed | Duration |
10 | Injection ($$$) or Calcidiol or Calcitriol | D - Slow C -Fast | Long |
10 | Sun/UVB | Slow | Long |
10 | Topical (skin patch/cream, vagina) | Slow Fast nano | Normal |
9 | Nanoemulsion -mucosal perhaps activates VDR | Fast | Normal |
9? | Inhaled (future) | Fast | Normal |
8 | Bio-D-Mulsion Forte | Normal | Normal |
6 | Water soluble (Bio-Tech) | Normal | Normal |
4 | Sublingual/spray (some goes into gut) | Fast | Normal |
3 | Coconut oil based | Slow | Normal |
2 | Food (salmon etc.) | Slow | Normal |
2 | Olive oil based (majority) | Slow | Normal |
10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
Gut category listing contains the following
- Ulcerative Colitis and Vitamin D - many studies 12+
- "celiac disease" OR CD 1830 items July 2019
- IBS or IBD or IRRITABLE BOWEL in title of 41 VitaminDWiki pages as of Aug 2022
- Gut-Friendly forms of vitamin D
- such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .
Overview Gut and vitamin D has the following summary
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019) - All items in category gut and vitamin D
209 items Diverticular disease:12X reduction if low Vitamin D and given 100,000 IU monthly – RCT Aug 20209795 visitors, last modified 21 Mar, 2021, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 15291 DDH vs years.jpg admin 21 Mar, 2021 40.67 Kb 1071 15290 DDH Sci-Hib.pdf admin 21 Mar, 2021 748.36 Kb 394 14245 Paradigm shift.pdf admin 01 Sep, 2020 527.39 Kb 585 14244 DD complications.jpg admin 01 Sep, 2020 77.05 Kb 1256 14243 Higher Serum Levels of Vitamin D Are Associated With a Reduced Risk of Diverticulitis.pdf admin 01 Sep, 2020 43.81 Kb 492