Table of contents
- Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function
- VitaminDWiki -
36 studies in both categories Pregnancy and Breathing - See also: Smoking reduces vitamin D - many studies
- See also: Overview Asthma and Vitamin D
Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function
J Allergy Clin Immunol . 2022 Nov 15;S0091-6749(22)01512-3. doi: 10.1016/j.jaci.2022.10.030 publisher charges $36 for the pdf
Hanna M Knihtilä 1 , Mengna Huang 2 , Nicole Prince 2 , Benjamin J Stubbs 2 , Vincent J Carey 2 , Nancy Laranjo 2 , Hooman Mirzakhani 2 , Robert S Zeiger 3 , Leonard B Bacharier 4 , George T O'Connor 5 , Augusto A Litonjua 6 , Scott T Weiss 2 , Jessica Lasky-Su 7
Background: Prior studies suggest that vitamin D may modify the effects of environmental exposures, however, none have investigated gestational vitamin D and cumulative tobacco smoke exposure (TSE) throughout pregnancy and early life.Objective: We investigated the effects of early life TSE on child lung function and the modulatory effects of gestational vitamin D on this association.
Methods: The Vitamin D Antenatal Asthma Reduction Trial recruited nonsmoking pregnant women and followed the mother-child pairs to age 6 years. TSE was assessed with questionnaires and plasma cotinine measurements in the mothers (10-18 and 32-38 gestational weeks) and children (1, 3, and 6 years). Cumulative TSE was calculated from the repeated cotinine measurements. 25-hydroxyvitamin D (25[OH]D) levels were measured at 10-18 and 32-38 gestational weeks. Lung function was assessed at 6 years with spirometry and impulse oscillometry.
Results: Of the 476 mother-child pairs, 205 (43%) had increased cotinine levels at ≥1 time point. Cumulative TSE was associated with decreased FEV1 (β -0.043 L, P=0.018) and increased respiratory resistance (R5; β 0.060 kPa/L/s, P=0.002). This association persisted in subjects with insufficient (<30 ng/ml) 25(OH)D levels throughout pregnancy (β 0.077 kPa/L/s, P=0.016 for R5) but not among those with sufficient levels throughout pregnancy.
Conclusion: Cumulative TSE from pregnancy to childhood is associated with dose- and duration-dependent decreases in child lung function at 6 years even in the absence of reported maternal smoking. Gestational vitamin D may modulate this effect and have therapeutic potential for minimizing the adverse effect of TSE on lung throughout early life.
VitaminDWiki -
36 studies in both categories Pregnancy and Breathing This list is automatically updated
- Microplastics suspected to cause Digestive, Reproductive, and Respiratory problems (mice and women) - Dec 2024
- 40 cents of Vitamin D given once during pregnancy reduced respiratory problems by 3% – May 2023
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Resulting childhood Asthma cut in half if 4,400 IU Vitamin D daily while pregnant - RCT April 2023
- Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
- Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Childhood Asthma risk greatly reduced if mothers were given 4,400 IU Vitamin D daily – RCT 2019
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018
- Pregnant women with low vitamin D (e.g. asthmatics) were more likely to have infants with vitamin D problems (asthmatics) – Jan 2018
- Lots of sugar while pregnant doubles asthma risk – 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Birth asphyxia 2.4 times more likely if mother was vitamin D deficient – 2016
- Asthma reduced 31 percent when Omega-3 taken during pregnancy – RCT Dec 2016
- Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Asthmatic pregnant women had 30 percent more preterm births if air pollution (vitamin D not mentioned) – March 2016
- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- Asthma trial underway - 4,000 IU during pregnancy - March 2014
- Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015
- Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015
- Low vitamin D during pregnancy associated with four health problems in children – Jan 2015
- Just 700 IU of vitamin D during pregnancy reduced rate of asthma at age 7 by 26 percent – Oct 2013
- Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013
- Season of birth associated with Pneumonia (10 %) and Multiple Sclerosis (30 %) – May 2013
- Dial D for danger – absurd editorial in Thorax – Oct 2012
- High maternal vitamin D resulted in 30 percent less infant problems with breathing – Nov 2011
- Smoking while pregnant lowers vitamin D and increases child asthma by 3.6 X – Aug 2011
- 800 IU Vitamin D while pregnant decrease child asthma by 2X- Sept 2010
- Vitamin D Newsletter May 2010
- Winter babies are more prone to food allergies
See also: Smoking reduces vitamin D - many studies
See also: Overview Asthma and Vitamin D
Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022Printer Friendly Follow this page for updates4121 visitors, last modified 19 Nov, 2022, This page is in the following categories (# of items in each category)