Serum vitamin D3 deficiency can affect the efficacy of sublingual immunotherapy in children with allergic rhinitis: a retrospective cohort study
J Thorac Dis . 2023 Feb 28;15(2):649-657. doi: 10.21037/jtd-22-1883. Epub 2023 Feb 22.
Liang Li # 1, Xiaojian Cui # 2, Xinjie Zhang # 3 4, Lisheng Zheng 2, Xuyuan Sun 1, Cuihong Yang 1, Jianbo Shu 3 4, Guangping Liu 1
Background: Sublingual immunotherapy (SLIT) is effective and convenient for many allergic patients but it is still ineffective for many children with allergic rhinitis (AR). In previous studies, most of the patients with poor efficacy of SLIT used the method of individualized adjustment of drug dosage. Currently, there are few reports on the relationship between serum vitamin D3 level and the efficacy of SLIT.
Methods: In this study, 153 patients with AR who received SLIT were selected as the study objects. All patients collected serum for vitamin D3 test before treatment. The clinical characteristics of the patients were collected, and all patients were regularly followed up for at least 6 months. The improvement rates were assessed according to the combined symptom medication score (CSMS). A receiver operating characteristic (ROC) curve was drawn, and the optimal cut-off point was determined according to the Youden index. Univariate and multivariate logistic regression were used to analyze the relationship between serum vitamin D3 and SLIT efficacy. The odds ratios (ORs) and 95% confidence intervals (CIs) were computed by logistic regression.
Results: Of 153 AR patients, 101 patients entered the final statistical analysis. According to CSMS, 29.7% of patients in low response (LR) group. The mean vitamin D3 level was (20.42±7.48) ng/mL. The optimal cutoff point for vitamin D3 was 22.25 ng/mL. Univariate logistic regression analysis of SLIT efficacy showed that whether the patient also had a food allergy (P<0.001) or asthma (P=0.011), whether they used acarid products (P=0.002), and whether vitamin D3 is sufficient (P=0.001) were significantly related to the efficacy of SLIT. Multivariate logistic regression analysis showed that after adjusting for whether the patient also had asthma and whether they had used acarid products, whether the patient also had a food allergy (OR: 12.13, 95% CI: 3.57-41.18, P<0.001) and whether vitamin D3 is sufficient (OR: 22.21, 95% CI: 4.04-122.30, P<0.001) were independent factors affecting the efficacy of SLIT.
Conclusions: Serum Vitamin D3 deficiency can affect the efficacy of SLIT in children with AR. This study provided a new therapeutic approach for SLIT patients with poor efficacy.
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VitaminDWiki – Interactions with Vitamin D contains
Interactions with Vitamin D hasVarious drugs decrease Vitamin D
Drug interactions with Vitamin D - many studies - Feb 2024
Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
Medications that appear to lower Vitamin D – Aug 2021
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Proton pump inhibitors decrease Vitamin D and Magnesium – Dec 2018
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
Antibiotics and Vitamin D are associated with many of the same diseases
More colas lower vitamin D by 3 ng– July 2014
A few Drugs increase Vitamin D
Contraceptives, Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Plastics, BPA, PCB and Vitamin D deficiency
Microplastics now causing problems in most life forms - many studies
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D production - many studies
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
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