1289 genes changed with higher doses of Vitamin D - RCT Dec 2019

Randomized Controlled Trial lasting 24 weeks with 30 healthy adults of mixed race and sex

• 291 genes improved expression by 2000 IU of vitamin D – RCT March 2013
  • Previous study by same authors

See also VitaminDWik

• 54 genes significantly affected by Vitamin D (50,000 IU weekly for 12 weeks) – May 2021
• Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
• Benefits of Vitamin D often limited by genes
• Gene activation by high dose vitamin D - both quick and long term - April 2015

Genes and Pregnancy

• Vitamin D genes and pregnancy – 7th study - Sept 2017
• 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018
• 5839 genes changed during pregnancy (many genes were related to Vitamin D) – Oct 2016

Genes and MS

• Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
• 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013

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Future Vitamin D gene studies could examine the gene changes:

• to the 35+ genes associated with Vitamin D
  • Vitamin D Receptor, Vitamin D Binding Protein, etc.
• If also use any of the 12+ Vitamin D Receptor activators - such as Resveratrol
• Associated with the immune system
• In tissues rather than just the blood
• Gut genes
• If start RCT with low levels of vitamin D
• If use infrequent dosing (non-daily)
  • Many studies have found better treatment when Vitamin D is given less frequently
  • Due to genes?
• If use UVB instead of Vitamin D
• If the person has specific health problems
• If have a poor vitamin D response
• If add co-factors, e.g. Magnesium and Omega-3
• If use a loading dose

Graphic of the study results by Dr. Raimund von Helden

Graphic and web page in German
Title translated from German: Vitamin D commands over 1200 genes - but only at a vitamin D level of 78 ng / ml
Graphics by GRH: 8X more genes changed

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Vitamin D Receptor

Vitamin D Receptor category has the following

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

10+ Vitamin D Receptor studies have overlaps to Health Problems

• VDR & Diabetes 24 studies
• VDR & Breathing 25 studies
• VDR & Breast Cancer 24 studies
• VDR & Cancer - general 23 studies
• VDR & Obesity 17 studies
• VDR &Multiple Sclerosis 24 studies

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Vitamin D Binding Protein

MS and Vitamin D Binding Protein:

TB and Vitamin D Binding Protein:

Breathing and Vitamin D Binding Protein:

Infant-Child and Vitamin D Binding Protein:

Pregnancy and Vitamin D Binding Protein: