Fluoride reduces Vitamin D and Magnesium - many studies

Note: I have filtered out Fl, Cl, etc. out of my drinking water for decades
Currently using Zero Water filter Amazon

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12+ VitaminDWiki pages with FLUORIDE in the title

This list is automatically updated

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VitaminDWiki – Interactions with Vitamin D contains

Interactions with Vitamin D has 126 items

Various drugs decrease Vitamin D
Drug interactions with Vitamin D - many studies - Feb 2024
Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
Medications that appear to lower Vitamin D – Aug 2021
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Proton pump inhibitors decrease Vitamin D and Magnesium – Dec 2018
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
Antibiotics and Vitamin D are associated with many of the same diseases
More colas lower vitamin D by 3 ng– July 2014
A few Drugs increase Vitamin D
Contraceptives,   Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Plastics, BPA, PCB and Vitamin D deficiency
Microplastics now causing problems in most life forms - many studies
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D production - many studies
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
Smoking   Coffee

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>600 Fluoride studies at GreenMedInfo - Nov 2024

  342 PubMed abstracts
356 items in GreeMedInfo
__Fluoride Literally Turns the Pineal Gland to Stone, Research Suggests Nov 2024

• Pineal gland calcification is associated with: Alzheimer Disease, Bipolar Disease, Circadian Dysregulation, Hormone Imbalances: Low Melatonin, Insomnia, Low Back Pain, Parkinson Disease, Schizophrenia, Sleep Disorders, Stroke

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RFK Jr.’s views on fluoride aren’t as crazy as you might think - 4 studies discussed by Washington Post - Nov 2024

Washington Post

• A JAMA Pediatrics study: women who drank fluoridated water during pregnancy had children with lower IQ scores at ages 3 to 4 years old."
• "... IQ scores of boys born to women with higher fluoride consumption were nearly 4.5 points lower."

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how does Fluoride in the water reduce Vitamin D in the blood? Asked Perplexity AI Nov 2024

Based on the search results, fluoride in drinking water can significantly impact vitamin D levels through several mechanisms:
Direct Correlation
Research has demonstrated a strong negative correlation between water fluoride levels and vitamin D in the blood. People living in areas with high fluoride concentrations (>1.5 mg/L) are five times more likely to develop severe vitamin D deficiency   1 (VitaminDWiki)   3
Mechanisms of Action
Calcium Disruption

• Fluoride interferes with calcium metabolism and transport across cell membranes   2
• This disruption affects the renal tubules and plasma membrane function   4
• The interference leads to calcium depletion in bone structures and abnormal calcium concentrations in blood   2

Hormonal Impact

• High fluoride exposure can damage the parathyroid gland, leading to hyperparathyroidism   2
• This affects the regulation of both calcium and vitamin D metabolism   4
• The disruption creates a cascade effect on vitamin D-related hormones   4

Clinical Evidence
Multiple studies have confirmed this relationship:

• Hospital-based studies show significant negative correlation between water fluoride and vitamin D levels (correlation coefficient = -0.777)   7
• Research demonstrates that people in fluoride-endemic areas have higher odds of severe vitamin D deficiency   3
• The association remains significant even when controlling for diet, sunshine exposure, and supplementation   4

Historical Context
Interestingly, there is evidence that the relationship between vitamin D deficiency and dental health was historically downplayed in favor of fluoride treatments, despite clinical trial evidence supporting vitamin D's role in dental health   6

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Far more vitamin D deficiency if high fluoride in water - Jan 2021

The association of fluoride in drinking water with serum calcium, vitamin D and parathyroid hormone in pregnant women and newborn infants
https://doi.org/10.1038/s41430-020-00707-2
 Download the PDF from Sci-Hub via VitaminDWiki

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Federal judge ruled that EPA has allowed too much fluoride in drinking water (lowering IQ of infants) - Sept 2024

TrialSiteNews

• "Currently, more than 200 million Americans, or about 75% of the population, drink fluoridated water."
• "A key study found that a pregnant woman with 0.28 mg/L of fluoride in her urine could expect a one-point drop in her child’s IQ. Many pregnant women in the U.S. have fluoride levels that exceed this amount. "
• “Plaintiffs have proven, by a preponderance of the evidence, that water fluoridation at the level of 0.7 mg/L – the prescribed optimal level of fluoridation in the United States – presents an unreasonable risk of injury to health or the environment, ..."

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Maternal Urinary Fluoride and Child Neurobehavior at Age 36 Months (Vit D, Mg not mentioned) - May 2024

JAMA Netw Open. 2024;7(5):e2411987. doi:10.1001/jamanetworkopen.2024.11987
Ashley J. Malin, PhD1,2; Sandrah P. Eckel, PhD3; Howard Hu, MD, MPH, ScD3; et alE. Angeles Martinez-Mier, PhD, DDS, MSD4; Ixel Hernandez-Castro, PhD3; Tingyu Yang, MS3; Shohreh F. Farzan, PhD3; Rima Habre, ScD3; Carrie V. Breton, ScD3; Theresa M. Bastain, PhD3

Key Points

• Question Is prenatal fluoride exposure associated with child neurobehavior in a US-based sample?
• Findings In this cohort study of 229 pregnant women and their children, a 0.68 mg/L (ie, 1 IQR) increase in specific gravity–adjusted maternal urinary fluoride during pregnancy was associated with nearly double the odds of T scores for total child neurobehavioral problems being in the borderline clinical or clinical range.
• Meaning These findings suggest that prenatal fluoride exposure may increase risk of neurobehavioral problems among children living in an optimally fluoridated area in the US.

Abstract
Importance Recent studies in Canadian and Mexican populations suggest an association of higher prenatal fluoride exposure with poorer neurobehavioral development, but whether this association holds for US-based populations is unknown.

Objective To examine associations of third trimester maternal urinary fluoride (MUF) with child neurobehavior at age 3 years in the US.

Design, Setting, and Participants This prospective cohort study utilized urine samples archived from 2017 to 2020 and neurobehavioral data assessed from 2020 to 2023 from the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) pregnancy cohort, which consisted of predominately Hispanic women residing in Los Angeles, California. Cohort eligibility criteria at recruitment included being 18 years of age or older, less than 30 weeks’ gestation, and a fluent English or Spanish speaker. Exclusion criteria included having a disability preventing participation or provision of informed consent, being HIV positive or incarcerated, and having a multiple gestation pregnancy. There were 263 mother-child pairs who completed the 3-year study visit. In this analysis, women who reported prenatal smoking were excluded. Data analysis was conducted from October 2022 to March 2024.

Exposure Specific gravity-adjusted MUF (MUFSG), a biomarker of prenatal fluoride exposure.

Main Outcomes and Measures Neurobehavior was quantified using the Preschool Child Behavior Checklist (CBCL), which included composite scores for Total Problems, Internalizing Problems, and Externalizing Problems. CBCL composite T scores range from 28 to 100. T scores from 60 to 63 are in the borderline clinical range, whereas scores above 63 are in the clinical range. Linear and logistic regression models adjusted for covariates were conducted.

Results A total of 229 mother-child pairs (mean [SD] maternal age, 29.45 [5.67] years; 116 female children [50.7%] and 113 male children [49.3%]) who had MUFSG measured were included in the study. Median (IQR) MUFSG was 0.76 (0.51-1.19) mg/L, and 32 participants (14.0%) had a Total Problems T score in the borderline clinical or clinical range. A 1-IQR (0.68 mg/L) increase in MUFSG was associated with nearly double the odds of the Total Problems T score being in the borderline clinical or clinical range (odds ratio, 1.83; 95% CI, 1.17-2.86; P = .008), as well as with a 2.29-point increase in T score for the Internalizing Problems composite (B = 2.29; 95% CI, 0.47-4.11; P = .01) and a 2.14-point increase in T score for the Total Problems composite (B = 2.14; 95% CI, 0.29-3.98; P = .02).

Conclusions and Relevance In this prospective cohort study of mother-child pairs in Los Angeles, California, prenatal fluoride exposure was associated with increased neurobehavioral problems. These findings suggest that there may be a need to establish recommendations for limiting fluoride exposure during the prenatal period.
 Download the PDF from VitaminDWiki

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The maternal fluoride publication was delayed for years by the CDC, which has not changed its position - Aug 2024

CDC Stands by Water Fluoridation After Report Linking Fluoride to Lower IQs in Kids Finally Published ChildrensHealthDefense