Table of contents
- Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis - Oct 2022
- Similar meta-analysis: only 2 studies used > 3,000 IU daily ==> 4X reduction in mortality - March 2023
- VitaminDWiki Mortality pages with CANCER in the title (35 as of Nov 2022)
- Examples of successful Cancer trials: 4,000 IU, measure D levels, add Omega-3, etc.
Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis - Oct 2022
Heliyon . 2022 Oct 28;8(11):e11290. doi: 10.1016/j.heliyon.2022.e11290
Huzaifa Ahmad Cheema 1 2 , Maurish Fatima 2 , Abia Shahid 1 2 , Oumnia Bouaddi 3 , Anas Elgenidy 4 , Aqeeb Ur Rehman 2 , Salah Eddine Oussama Kacimi 5 , Mohammad Mehedi Hasan 6 , Ka Yiu Lee 7
Introduction: Previous randomized controlled trials (RCTs) and meta-analyses of RCTs evaluating vitamin D supplementation for the prevention of cancer incidence and mortality have found inconsistent results and no meta-analysis has assessed the quality of the evidence available. We, therefore, aimed to perform an updated meta-analysis by including recent large-scale RCTs and assessing the quality of the pooled evidence.
Methods: We searched several databases and trial registers from inception to April 2022. We used a random-effects model to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs). We used the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considerations to evaluate the certainty of evidence.
Results: We included 13 RCTs in our study. Vitamin D supplementation had no effect on the risk of total cancer incidence (RR 0.99, 95% CI: 0.94-1.04; I 2 = 0%), total cancer mortality (RR 0.93, 95% CI: 0.84-1.03; I 2 = 24%) and total mortality (RR 0.92, 95% CI: 0.82-1.04; I 2 = 36%). The overall quality of evidence was high for all outcomes.
Discussion: Vitamin D supplementation is ineffective in reducing total cancer incidence and mortality in largely vitamin D-replete older adult populations. Future research should be based on populations with a higher prevalence of vitamin D deficiency and should involve more extended follow-up periods.
Study protocol: PROSPERO database, CRD42021285401.
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Similar meta-analysis: only 2 studies used > 3,000 IU daily ==> 4X reduction in mortality - March 2023
Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials
Download the PDF from VitaminDWiki
VitaminDWiki Mortality pages with CANCER in the title (35 as of Nov 2022)
This list is automatically updated
Examples of successful Cancer trials: 4,000 IU, measure D levels, add Omega-3, etc.
- Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016
- Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies
- Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021
- Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015
- Low risk Prostate Cancer decreased with 4,000 IU of vitamin D – July 2012
- 2,000 IU of vitamin D and Omega-3 reduced Cancer death rate bv 40% (normal weight) – VITAL RCT Nov 2020
- Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022
- Overview Cancer-Colon and vitamin D has the following Colon Cancer Prevention chart