Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study
Cytokine, Volume 71, Issue 2, February 2015, Pages 132–138 https://doi.org/10.1016/j.cyto.2014.09.012
Tyler Barker a tyler.barker at imail.org , Victoria E. Rogers a, Mark Levy b, Jenna Templeton b, Howard Goldfine b, Erik D. Schneider b, Brian M. Dixon b, Vanessa T. Henriksen a, Lindell K. Weaver c, d, e
a The Physiology Research Laboratory, The Orthopedic Specialty Hospital, Murray, UT 84107, USA
b Research and Development, USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA
c Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA
d LDS Hospital, Salt Lake City, UT 84143, USA
e School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
Highlights
Vitamin D modulates cytokines and muscle performance.
Supplemental vitamin D increased 25(OH)D and 1,25(OH)D without altering work.
Supplemental vitamin D increased IFN-γ and IL-10 in vitamin D insufficient adults.
Wow – a journal just about Cytokines – 71st edition no less!!
4,000 and 8,000 IU doses were both tried
Did not matter dose size, just that blood levels were raised above 30 ng
See also VitaminDWiki
- Inflammation reduced when vitamin D supplementation raised level higher than 32 ng – meta-analysis May 2017
- Vitamin D in inflammatory diseases – Technical Review June 2014
- Inflammatory diseases: review of vitamin D, with many tables – May 2014
- Search VitaminDWiki for CYTOKINE 504 items not in PDF as of Feb 2020
- Omega-3 reduced vitamin D3 inflammation for obese – RCT Jan 2013
56 studies referenced this study as of Feb 2021
- The Role of Vitamin D in Suppressing Cytokine Storm in COVID-19 Patients and Associated Mortality - April 2020 FREE PDF
- Effect of vitamin D supplementation on selected inflammatory biomarkers in older adults: a secondary analysis of data from a randomised, placebo-controlled trial
- Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia - Oct 2019 PDF 800 IU to children for 6 months
Download the PDF from Sci-Hub VitaminDWiki
Chart appears to show that all Cytokines DECREASE with sufficient Vitamin D
The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m2; serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randomly assigned (double blind) to one of three groups: (1) placebo (n = 15), or supplemental vitamin D (cholecalciferol) at (2) 4000 (n = 14) or (3) 8000 IU (n = 17). Supplements were taken daily for 35 days. Fasting blood samples were obtained before (Baseline, Bsl) and 35-days after (35-d) supplementation. Serum 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)D), cytokines, and intact parathyroid hormone with calcium were measured in each blood sample.
Supplemental vitamin D increased serum 25(OH)D (4000 IU, ≈29%; 8000 IU, ≈57%) and 1,25(OH)D (4000 IU, ≈12%; 8000 IU, ≈38%) without altering intact parathyroid hormone or calcium.
The vitamin D metabolite increases in the supplemental vitamin D groups (n = 31) were dependent on initial levels as serum 25(OH)D (r = −0.63, p < 0.05) and 1,25(OH)D (r = −0.45, p < 0.05) at Bsl correlated with their increases after supplementation.
Supplemental vitamin D increased interferon (IFN)-γ and interleukin (IL)-10 in subjects that were vitamin D insufficient (serum 25(OH)D < 29 ng/mL) compared to sufficient (serum 25(OH)D ⩾ 30 ng/mL) at Bsl.
We conclude that supplemental vitamin D increase a pro- and anti-inflammatory cytokine in those with initially low serum 25(OH)D.