Does vitamin D play a significant role in type 2 diabetes?
BMC Endocr Disord. 2015 Feb 26;15(1):5. doi: 10.1186/s12902-015-0003-8.
Sheth JJ1, Shah A2, Sheth FJ3, Trivedi S4, Lele M5, Shah N6, Thakor P7, Vaidya R8.
94% of the participants has < 20 ng of vitamin D
Glycation control inverse relationship in the other 6% (> 20 ng)
See also VitaminDWiki
Overview Diabetes and vitamin D
Why India's vitamin D deficiency is grim - 40 pages Feb 2014
80 percent of young adults had low vitamin D tests in Mumbai India - 2011
Diabetes leads to many diseases - need to restore the vitamin D levels
Diabetes ==> Cognitive impairment
Diabetes ==> Vertebral fracture in men only
Diabetes ==> Rheumatoid Arthritis
Diabetes ==> Pancreatic Cancer
Diabetes ==> Alzheimer's
Diabetes <==> Depression
VitaminDWiki - Dark Skin Diabetics and Vitamin D - many studies
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BACKGROUND:
Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects.
METHODS:
Present study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled study subjects were investigated for biochemical parameters like FBS, PPBS, HbA1c, FI, HOMA-IR and 25OHD levels in blood.
RESULTS:
Vitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c or HOMA-IR in T2DM cases (p = 0.057 & p = 0.257 respectively) and in control subjects (p = 0.675 & p = 0.647 respectively).
CONCLUSION:
Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.
PMID: 25887335
Glycation control
B. Relationship between vitamin D non-deficient T2DM cases and HbA1c.
D. Relationship between vitamin D non-deficient Controls and HbA1c.
Clipped from PDF
. . . “low serum vitamin D levels in 70% to 100% populations across India.”
“This is likely to be due to
- increased skin pigmentation,
- low exposure to direct sunlight,
- obesity and malabsorption”