Can weekly vitamin d dosing adequately treat vitamin d deficiency in pregnancy?
American Journal of Obstetrics and Gynecology, Volume 216, Issue 1, Supplement, January 2017, Pages S380-S381
Brianne Bimson, Lois Brustman, Zainab Al Ibraheemi, Kimberly Herrera, Barak Rosenn
Mount Sinai West Hospital, new york, NY
This is 1 of 875 posters to be presented at 37th Annual Meeting of the Society for Maternal Fetal Medicine - Jan 2017
Behind a $36 paywall - which I paid
Publisher provided no abstract
- Both arms of the RCT got 400 IU daily
- Vitamin D levels were measured 8 to 12 weeks after the start of the trial
- No indication why they stopped the Vitamin D supplementation at 8 weeks
As would be expected the vitamin D levels dropped a lot after the supplementation stopped - Average level achieved at 8 weeks was 48 nanograms
- Some got above 70 nanograms
This is probably due to taking the vitamin D sample within a few days of the last 50,000 IU dose - 2 had their vitamin D levels drop
- 84% became vitamin D sufficient at 8 weeks (> 30 ng)
- No indication that they recorded the outcome differences between the RCT ARMS
Have thought about this study for a day and have not been able to come up with a single reason for the study
See also VitaminDWiki
Healthy pregnancies need lots of vitamin D has the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for details
Problem | Vit. D Reduces | Evidence |
| 0. Chance of not conceiving | 3.4 times | Observe |
| 1. Miscarriage | 2.5 times | Observe |
| 2. Pre-eclampsia | 3.6 times | RCT |
| 3. Gestational Diabetes | 3 times | RCT |
| 4. Good 2nd trimester sleep quality | 3.5 times | Observe |
| 5. Premature birth | 2 times | RCT |
| 6. C-section - unplanned | 1.6 times | Observe |
| Stillbirth - OMEGA-3 | 4 times | RCT - Omega-3 |
| 7. Depression AFTER pregnancy | 1.4 times | RCT |
| 8. Small for Gestational Age | 1.6 times | meta-analysis |
| 9. Infant height, weight, head size within normal limits | RCT | |
| 10. Childhood Wheezing | 1.3 times | RCT |
| 11. Additional child is Autistic | 4 times | Intervention |
| 12.Young adult Multiple Sclerosis | 1.9 times | Observe |
| 13. Preeclampsia in young adult | 3.5 times | RCT |
| 14. Good motor skills @ age 3 | 1.4 times | Observe |
| 15. Childhood Mite allergy | 5 times | RCT |
| 16. Childhood Respiratory Tract visits | 2.5 times | RCT |
RCT = Randomized Controlled Trial