Joint association of sedentary behavior and vitamin D status with mortality among cancer survivors
BMC Medicine volume 21, Article number: 411 (2023)
Yu Yu, Sijing Cheng, Hao Huang, Yu Deng, Chi Cai, Min Gu, Xuhua Chen, Hongxia Niu & Wei Hua
Background
Sedentary behavior and vitamin D deficiency are independent risk factors for mortality in cancer survivors, but their joint association with mortality has not been investigated.
Methods
We analyzed data from 2914 cancer survivors who participated in the National Health and Nutrition Examination Survey (2007–2018) and followed up with them until December 31, 2019. Sedentary behavior was assessed by self-reported daily hours of sitting, and vitamin D status was measured by serum total 25-hydroxyvitamin D (25(OH)D) levels.
Results
Among 2914 cancer survivors, vitamin D deficiency was more prevalent in those with prolonged daily sitting time. During up to 13.2 years (median, 5.6 years) of follow-up, there were 676 deaths (cancer, 226; cardiovascular disease, 142; other causes, 308). The prolonged sitting time was associated with a higher risk of all-cause and noncancer mortality, and vitamin D deficiency was associated with a higher risk of all-cause and cancer mortality. Furthermore, cancer survivors with both prolonged sitting time (≥ 6 h/day) and vitamin D deficiency had a significantly higher risk of all-cause (HR, 2.05; 95% CI: 1.54–2.72), cancer (HR, 2.33; 95% CI, 1.47–3.70), and noncancer mortality (HR, 1.91; 95% CI, 1.33–2.74) than those with neither risk factor after adjustment for potential confounders.
Conclusions
In a nationally representative sample of U.S. cancer survivors, the joint presence of sedentary behavior and vitamin D deficiency was significantly associated with an increased risk of all-cause and cancer-specific mortality.
 Download the PDF from VitaminDWiki
37+ VitaminDWiki pages have both CANCER and SURVIVE in the title
This list is automatically updated
Items found: 6
Search 2 words within a category
XX+ VitaminDWiki Mortality pages have CANCER in the title
This list is automatically updated
Items found: 34
Title |
|
Modified |
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 |
|
13 Jun, 2017 |
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
|
06 Mar, 2014 |
Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 |
|
17 Aug, 2021 |
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 |
|
15 Oct, 2021 |
Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 |
|
07 May, 2019 |
Cancer incidence and mortality not changed by small Vitamin D doses – meta-analysis Oct 2022 |
|
08 Nov, 2022 |
Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 |
|
17 Jun, 2014 |
Cancer is leading cause of death - Vitamin D and Receptor activators help |
|
09 Nov, 2019 |
Cancer mortality not reduced by small vitamin D doses - Sept 2021 |
|
21 Sep, 2021 |
Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 |
|
03 Jul, 2022 |
Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 |
|
26 Nov, 2018 |
Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 |
|
31 Dec, 2020 |
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
|
12 May, 2014 |
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 |
|
05 Jul, 2019 |
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 |
|
30 Sep, 2014 |
Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 |
|
15 Jun, 2016 |
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 |
|
08 Apr, 2014 |
Death of women from cancer 24 percent less likely if 20 ng more vitamin D – meta-analysis Sept 2013 |
|
01 May, 2014 |
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 |
|
10 Jan, 2021 |
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 |
|
09 Nov, 2020 |
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 |
|
09 Nov, 2014 |
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 |
|
29 Dec, 2017 |
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
|
08 May, 2014 |
More US deaths due to cancer than heart if dark skinned – Sept 2012 |
|
18 Sep, 2012 |
Mortality and Cancer varies with latitude in France too – 2010 |
|
26 Oct, 2012 |
Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 |
|
08 Nov, 2019 |
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 |
|
05 Jul, 2019 |
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 |
|
14 Oct, 2018 |
Solar radiation, vitamin D and cancer incidence and mortality in Norway |
|
13 Apr, 2010 |
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 |
|
13 Jan, 2018 |
Vitamin D and Cancer Mortality – review Jan 2013 |
|
17 Sep, 2013 |
Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 |
|
13 Apr, 2019 |
Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival |
|
10 Sep, 2018 |
Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 |
|
10 Sep, 2019 |