21 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 2022

Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

Biomedicine & Pharmacotherapy https://doi.org/10.1016/j.biopha.2022.112965
Montserrat Torres, Guiomar Casado, Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel López-Wolf, José Sanz-Moreno, Pablo Ryan-Murua, María Luisa Taboada-Martínez, María Rosa López-Huertas, Miguel Cervero, Mayte Coiras – Multidisciplinary Group of Study of COVID-19 (MGS-COVID)1 Madrid

Highlights

• Treatment with 10,000 IU/day of cholecalciferol was safe during severe COVID-19.
• Anti-inflammatory cytokine IL-10 was significantly increased in 10,000 IU/day group.
• Individuals who received 10,000 IU/day of cholecalciferol showed increased CD4 count.
• Individuals with ARDS in 10,000 IU/day group stayed at the hospital less time.
• The 10,000 IU/day group showed increased antiviral cytotoxic activity.

Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment and improve cytotoxic response against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved in patients with COVID-19 pneumonia and levels of 25-hydroxyvitamin D (25(OH)D) of 14.8 ng/mL (SD: 6.18) to test antiviral efficacy, tolerance and safety of 10,000 IU/day of cholecalciferol (vitamin D3) for 14 days, in comparison with 2,000 IU/day.
After supplementation, mean serum 25(OH)D levels increased to

• 19 ng/mL on average in 2,000 IU/day versus
• 29 ng/mL in 10,000 IU/day group (p <0.0001).

Although levels of inflammatory cytokines were not modified by treatment with 10,000 IU/day, there was an increase of anti-inflammatory cytokine IL-10 and higher levels of CD4+ T cells, with predominance of T central memory subpopulation.
Cytotoxic response against pseudotyped SARS-CoV-2 infected cells was increased more than 4-fold in patients who received 10,000 IU/day. Moreover, levels of IFN? were significantly higher in this group.

Beneficial effect of supplementation with 10,000 IU/day was also observed in participants who developed ARDS and stayed at the hospital for 8.0 days, whereas those who received 2,000 IU/day stayed for 29.2 days (p=0.0381). Administration of high doses of vitamin D3 as adjuvant of the standard care treatment during hospitalization for COVID-19 may improve the inflammatory environment and cytotoxic response against pseudotyped SARS-CoV-2 infected cells, shortening the hospital stay and, possibly, improving the prognosis.
 Download the PDF from VitaminDWiki

Graphical summary

Clipped from PDF
The inclusion criteria for the participants in the study were being adults (>18 years old) hospitalized for at least seven days from the onset of COVID-19 symptoms, which is when usually began the inflammatory phase, with a diagnosis of pneumonia due to COVID-19

Speculation:
No hospitalization if had gotten high dose vitamin D at COVID symptom onset
VitaminDWiki: Take lots of Vitamin D at first signs of COVID

thanks to Gustavo Bellini for pointing out this study

VitaminDwiki- Items in both categories Virus and Intervention (43 items)

This list is automatically updated

VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries

• 
  • The above image is automatically updated

VitaminDWiki pages with HIGH-DOSE in title (63 as of April 2022)

This list is automatically updated