Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast Cancer
Anticancer Research March 2014 vol. 34 no. 3 1163-1166
SHARIF B. MOHR 1⇑, EDWARD D. GORHAM 1,2, JUNE KIM 1, HEATHER HOFFLICH 2 and CEDRIC F. GARLAND 1,2
1 Scientific Programs Office, Code 01A, Naval Health Research Center, San Diego, CA, U.S.A.
2 Department of Family and Preventive Medicine 0620, University of California, San Diego, La Jolla, CA, U.S.A.
Correspondence to: Sharif Mohr, Scientific Programs Office, Code 01A, Naval Health Research Center, San Diego, CA 92106, U.S.A. sbmohr75 at gmail.com
Background/Aim: To determine whether higher serum 25-hydroxyvitamin D [25(OH)D] at diagnosis is associated with longer survival of patients with breast cancer.
Materials and Methods: A meta-analysis was performed of five studies of the relationship between 25(OH)D and mortality from breast cancer. A pooled hazard ratio was calculated using a random-effects model. The Der Simonian-Laird test was used to assess homogeneity.
Results: Higher serum concentrations of 25(OH)D were associated with lower case-fatality rates after diagnosis of breast cancer. Specifically, patients in the highest quintile of 25(OH)D had approximately half the death rate from breast cancer as those in the lowest.
Conclusion: High serum 25(OH)D was associated with lower mortality from breast cancer. Serum 25(OH)D in all patients with breast cancer should be restored to the normal range (30-80 ng/ml), with appropriate monitoring. Clinical or field studies should be initiated to confirm that this association was not due to reverse causation.
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Studies in all 3 categories: Breast Cancer, Meta-analysis and Mortality
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 same conclusion as the current study
- 3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013 Vitamin D also helps prevent Breast Cancer
- Overview Breast Cancer and Vitamin D
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
- Chart of Vitamin D levels vs disease - Grassroots Health June 2013 contains the following chart of INCIDENCE, not mortality
All Breast Cancer Meta-analysis studies in VitaminDWiki
- Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella July 2024
- Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023
- Breast Cancer risk - meta-analysis of 50 studies - Dec 2019
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020
- Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019
- Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013
- Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013
- 3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Meta-analysis not find low vitamin D years before breast cancer – Aug 2010
- Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010
- Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010
- Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010
Studies in all 3 categories: Cancer, Meta-analysis and Mortality
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013