In vitro fertilization and Vitamin D – many studies

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IVF newborns had ~2 ng/mL higher Vitamin D levels - April 2024

Vitamin D3 among neonates born after in vitro fertilization compared with neonates from the general population
Acta Obstet Gynecol Scand. 2024;00:1–10. DOI: 10.1111/aogs.14819
Karen Christina Walker1© | Sofie Gry Pristed2,3 | Fanney Thorsteinsdottir1,4 Ina Olmer Specht1,4© | Arieh Cohen5 | Berit Lilienthal Heitmann 1,3,6© |
Ulrik Schi0ler Kesmodel 2,7

Introduction: Sufficient levels of vitamin D have been associated with higher chances for both clinical pregnancy and live birth among women undergoing assisted repro­ductive techniques, whereas low levels of maternal vitamin D have been associated with preeclampsia and late miscarriage. In Denmark, subgroups at risk for low vitamin D levels, including neonates and toddlers, are recommended to use supplementation. The aim was to study the level of vitamin D3 among neonates born after in vitro ferti­lization compared with neonates from the general population.

Material and methods: In this cohort study a random sample of 1326 neonates repre­senting the general population and 1200 neonates conceived by in vitro fertilization born in Denmark from 1995 to 2002 were identified from registries covering the whole Danish population. Information on use of assisted reproduction was collected from the Danish In Vitro Fertilization register, ICD-10 code: DZ358F. 25-Hydroxyvitamin D was measured from dried blood spots routinely collected by heel prick 48-72h after birth and corrected according to the hematocrit fraction for capillary blood of neonates. Linear regression analysis was performed, both crude and adjusted, for pre­defined putative confounders, identified through directed acyclic graphs.

Results: Vitamin D3 analysis could be performed from a total of 1105 neonates from the general population and 1072 neonates conceived by in vitro fertilization that were subsequently included in the study. The median vitamin D3 was 24.0 nmol/L (interquar­tile range [IQR] 14.1-39.3) and 33.0nmol/L (IQR 21.3-48.8) among neonates from the general population and neonates conceived by in vitro fertilization, respectively. The adjusted mean difference between neonates from the general population and those conceived by in vitro fertilization was 6.1 nmol/L (95% confidence interval 4.1–8.1)

Conclusions: In this study, children born after in vitro fertilization have a higher vitamin D3 than a random sample of neonates in Denmark.1
 Download the PDF from VitaminDWiki

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Note: Vitamin D is often given both before and during IVF treatment

I suspect that many of the women (who could afford IVF in the first place) also continue on with the Vitamin D during pregnancy

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Note: IVF facilities would probably lose business if they mentioned the huge fertility benefit of Vitamin D

In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars

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18+ VitaminDWiki pages have IVF or IN VITRO FERTILIZATION etc. in the title

This list is automatically updated

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VitaminDWiki – Vitamin D greatly improves Fertility

• Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
• In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
• Infertile patients 1.7X more-likely to become pregnant if take Vitamin D – meta-analysis Feb 2023
• Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis Aug 2020
• If diagnosed infertile, more likely to have live birth if Vitamin D fortification – Feb 2020
• Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
• Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
• Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
• Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
• IVF 4X more successful for white women with lots of vitamin D – many studies

Increased male Vitamin D increases fertility

• Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017
• Higher vitamin D results in 22% fewer abnormal sperm (Mendelian analysis) – May 2024
• Conception was 3.7X more likely if the male had a good level of Vitamin D – July 2022
• Far better sperm in fertility clinic if more than 30 ng of Vitamin D - June 2022
• Fertility (sperm) associated with vitamin D – meta-analysis Sept 2019
• Infertility - 71 percent of the time of BOTH partners had less than 20 ng of Vitamin D – Aug 2017
• Male fertility 4 X higher if high Vitamin D – Nov 2015
• Vitamin D somewhat assists reproduction – both the mother and the father – May 2014

Decreased Fertility if decreased Vitamin D Receptor

• Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
• Male Infertility is associated with poor Vitamin D Receptor – July 2021

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Fertility improved the most if give Vitamin D AND 1 or more Vitamin D Receptor Activators

For male and female before pregnancy
Perhaps 50,000 IU bi-weekly for several months before becoming pregnant
Daily supplement to activate the Vitamin D Receptor
Female to continue with both D and activator thru 6 months after birth

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VitaminDWiki – 50,000 IU of Vitamin D - many studies

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VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators

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VitaminDWiki - 24 studies in both categories Pregnancy and Vitamin D Receptor

This list is automatically updated

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VitaminDWiki - 7 studies in both categories Fertility and Vitamin D Receptor

This list is automatically updated