Vitamin D helps both the Innate and Adaptive immune systems

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The Immunostimulatory Properties of Vitamin D - May 2025

Haya Saudi J Life Sci https://doi.org/10.36348/sils.2025.v10i05.004
Khalil Ismail Abid Mohammed1 *, Sawsan H. Authman2, Sarmad M. Zeiny3, Saad Hasan Mohammed Ali4

Vitamin D has been associated with the regulation of bone metabolism. However, increasing evidence demonstrates a strong association between vitamin D signaling and many biological processes to that immunostimulatory and immunomodulatory effects on the immune system. the presence of the vitamin D receptor in multiple immune cells, such as monocytes, dendritic cells, and activated T cells, vitamin D with a novel role in modulating immunological functions and its subsequent role in the development or prevention of autoimmune diseases such as

• systemic lupus Erythematosus,
• Type-1 Diabetes mellitus and
• multiple sclerosis.

In the present review, the multiple and diverse effects of vitamin D on the immune system are reviewed.

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Vitamin D in the time of the coronavirus (COVID-19) pandemic - a clinical review from a public health and public mental health perspective - July 2021

Ther Adv Psychopharmacol 2021 Jul 9; doi: 10.1177/20451253211027699.
Ursula Werneke 1, Fiona Gaughran 2, David M Taylor 3

Individuals with serious mental disorders (SMD) may have a higher risk of vitamin D (VIT-D) deficiency. They also experience higher mortality because of coronavirus disease 2019 (COVID-19) infection. Therefore, we have conducted a comprehensive review to examine the significance of VIT-D for public health and public mental health during the ongoing COVID-19 pandemic. This review had three specific aims, from a global perspective to (a) create a profile of VIT-D and review the epidemiology of VIT-D deficiency, (b) explore VIT-D deficiency as risk factor for SMD and COVID-19 infections and (c) examine the effectiveness of VIT-D supplementation for both conditions. We found that, in terms of SMD, the evidence from laboratory and observational studies points towards some association between VIT-D deficiency and depression or schizophrenia. Mendelian randomisation studies, however, suggest no, or reverse, causality. The evidence from intervention studies is conflicting. Concerning COVID-19 infection, on proof of principle, VIT-D could provide a plausible defence against the infection itself and against an adverse clinical course. But data from observational studies and the first preliminary intervention studies remain conflicting, with stronger evidence that VIT-D may mitigate the clinical course of COVID-19 infection rather than the risk of infection in the first place. From a public health and public mental health point of view, based on the currently limited knowledge, for individuals with SMD, the benefits of VIT-D optimisation through supplementation seem to outweigh the risks. VIT-D supplementation, however, should not substitute for vaccination or medical care for COVID-19 infection.
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See also in VitaminDWiki

Immunity category
Autoimmune
Overview Diabetes and vitamin D
Overview MS and vitamin D
Search for INNATE and/or ADAPTIVE

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