- Genetic Polymorphisms (ApaI, FokI, BsmI, and TaqI) of the Vitamin D Receptor (VDR) Influence the Natural History and Phenotype of Crohn’s Disease
- VitaminDWiki Crohn's and Vitamin D - many studies 40 as of Feb 2025
- VitaminDWiki - The risk of 50+ diseases at least double with poor Vitamin D Receptor
- VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
- VitaminDWiki - Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020
- 13+ VitaminDWiki VDR pages have CROHN etc. in the title
Genetic Polymorphisms (ApaI, FokI, BsmI, and TaqI) of the Vitamin D Receptor (VDR) Influence the Natural History and Phenotype of Crohn’s Disease
Int. J. Mol. Sci. 2025, 26(5), 1848; https://doi.org/10.3390/ijms26051848
by Theodora KafentziORCID,Efthymios P. TsounisORCID,Evanthia Tourkochristou,Evdoxia Avramopoulou,Ioanna AggeletopoulouORCID,Georgios Geramoutsos, Christos SotiropoulosORCID, Ploutarchos PastrasORCID,Konstantinos Thomopoulos,Georgios Theocharis and Christos Triantos
Division of Gastroenterology, Department of Internal Medicine, Medical School, University of Patras, 26504 Patras, Greece
Vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) modulate vitamin D/VDR signaling, a key pathway in inflammatory bowel disease (IBD) pathogenesis. This study investigates how ApaI, BsmI, TaqI, and FokI SNPs affect IBD phenotype and progression. A total of 76 Crohn’s disease (CD) and 68 ulcerative colitis (UC) patients were genotyped. On initial bivariate analysis, the AA genotype of ApaI was accompanied by higher rates of penetrating (B3) CD (36.7% vs. 8.7%; p = 0.012). The FokI SNP was associated with disease location, with the ff genotype predisposing to CD and affecting the upper GI (36.4% vs. 7.7%; p = 0.044) or the colon (90.9% vs. 50.8%; p = 0.038). Moreover, patients harboring the ApaI A allele (AA/Aa) experienced higher rates of steroid-refractory or steroid-dependent CD.
In multivariate analyses, the aa genotype showed a
- protective effect against hospitalization (aOR = 0.17; p = 0.013) in CD,
- whereas the TT genotype emerged as an independent risk factor (aOR = 4.79; p = 0.044).
Moreover, the aa genotype was independently associated with a decreased risk of IBD-related surgery (aOR = 0.055; p = 0.014). VDR SNPs, particularly ApaI, influence disease phenotype, progression, and treatment response in CD. The aa genotype of ApaI appears to confer protection against adverse disease outcomes.
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Note: The changes of cellular Vitamin D (by VDR) are not noticed by blood tests - yet doctors still only consider blood tests
VitaminDWiki Crohn's and Vitamin D - many studies 40 as of Feb 2025
VitaminDWiki - The risk of 50+ diseases at least double with poor Vitamin D Receptor
VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators
VitaminDWiki - Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020
13+ VitaminDWiki VDR pages have CROHN etc. in the title
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