Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”
International Journal of Rheumatology. Volume 2017 (2017), Article ID 5491676, 8 pages. https://doi.org/10.1155/2017/5491676
Rheumatoid Arthritis category starts with
Highlights of RA studies in VitaminDWiki
RA worse if low Vitamin D
- Rheumatoid Arthritis score extrapolates to zero at 51 ng of Vitamin D (India) – June 2024
- Rheumatoid Arthritis is more severe if low vitamin D – July 2023
- Rheumatoid arthritis pain was 5.8 X more likely if low vitamin D – Aug 2017
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016
- Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis Jan 2016
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019
- Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D in rheumatoid arthritis-towards clinical application – April 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Rheumatoid arthritis, genes and vitamin D – May 2013
RA Treated by Vitamin D
- Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022
- Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
- Connective tissue disorders (Lupus, RA, etc) treated by vitamin D – May 2016
- 43 percent of Rheumatoid Arthritis patients have Vitamin D prescriptions (15 countries) – June 2017
- Big increase in vitamin D supplementation in just 2 years after Swiss rheumatology report – Dec 2013
- High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
- Note: Vitamin D receptor problems (such as RA) are best treated by infrequent large doses of Vitamin D
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Argentina, Austria, Egypt, France, Germany, Hungary, Italy, Korea, Morocco, Netherlands, Spain, Taiwan, UK, Uruguay, USA
Najia Hajjaj-Hassouni,1,2,3 Nada Mawani,1,2 Fadoua Allali,1,2 Hanan Rkain,1,2,4 Kenza Hassouni,5 Ihsane Hmamouchi,1,2 and Maxime Dougados6
- 1LIRPOS-URAC30, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
- 2Department of Rheumatology, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Salé, Morocco
- 3Innovation Center, Mohammed VI University for Health Sciences, Casablanca, Morocco
- 4Department of Physiology, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
- 5International School for Public Health, Mohammed VI University for Health Sciences, Casablanca, Morocco
- 6Department of Rheumatology, Hôpital Cochin, Paris Descartes University, Assistance Publique-Hôpitaux de Paris, EULAR Center of Excellence, INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France
Correspondence should be addressed to Najia Hajjaj-Hassouni
The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients’ RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27.3 ng/mL ± 15.1 0.1–151.
Status of vitamin D was insufficient in 54.6% and deficient in 8.5% of patients.
43% of RA patients were supplemented with vitamin D and absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency (). Finally, our study shows that the status of low levels of vitamin D is common in RA in different countries and under different latitudes. Absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency. Low levels of vitamin D were associated with patients characteristics (age, BMI, and educational level), RA (disease activity and corticosteroid dosage), and comorbidities (lung disease and osteoporosis therapy). This suggests the need for a particular therapeutic strategy to improve vitamin D status in RA patients.
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