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Each ng extra vitamin D associated with better breathing (and 2X better for smokers) – March 2018

Large Meta-Analysis in the CHARGE Consortium Provides Evidence For an Association of Serum Vitamin D With Pulmonary Function

Biorxiv Preprint, doi: https://doi.org/10.1101/144717


27,000 people
For each 1 nmol more vitamin D FEV1

  • 1.1 milliliter more if European Ancestry
  • 1.8 milliliter more if Afrian Ancestry

For each 1 nmol more Vitamin D the Total Capacity for European Ancestry

  • .1.7 millilitter if current or former smoker
  • 0.8 millilitter if never-smoker

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Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for the association of serum 25-hydroxyvitamin D [25(OH)D] and pulmonary function. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n=22,838) and five African ancestry (AA) cohorts (n=4,290) in the CHARGE Consortium. Data were analyzed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested.

Results were combined using fixed-effects meta-analysis.
Mean (SD) serum 25(OH)D was

  • 68 (29) nmol/L for EAs and
  • 49 (21) nmol/L for Aas.

For each 1 nmol/L higher 25(OH)D, forced expiratory volume in the first second (FEV1) was higher by

  • 1.1 mL in EAs (95% CI: 0.9,1.3; P=2.5×10-21) and

(1.8 mL (95% CI: 1.1,2.5; P=1.6×10-7) in AAs (Prace difference=0.06), and
forced vital capacity (FVC) was higher by

  • 1.3 mL in EAs (95% CI: 1.0,1.6; P=1.1×10-20) and
  • 1.5 mL (95% CI: 0.8,2.3; P=1.2×10-4) in AAs (Prace difference=0.56).

Among EAs, the 25(OH)D-FVC association was stronger in smokers: per 1nmol/L higher 25(OH)D,

  • FVC was higher by 1.7 mL (95% CI: 1.1,2.3) for current smokers and
  • 1.7 mL (95% CI: 1.2,2.1) for former smokers, compared to
  • 0.8 mL (95% CI: 0.4,1.2) for never smokers.

In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EAs, a stronger association was observed for smokers compared to never smokers, which supports the importance of vitamin D in vulnerable populations.

Created by admin. Last Modification: Monday July 9, 2018 15:46:06 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
10136 Vitamin D With Pulmonary Function.pdf admin 09 Jul, 2018 2.82 Mb 709