Early-Onset Colorectal Cancer 2X less likely if consume more than 450 IU of Vitamin D daily – Aug 2021

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Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors - July 2021

Hanseul Kim. Marla Lipsyc-Sharf, Xiaoyu Zong. Yin Cao §. Kimmie Ng §. Edward L. Giovannucci §
Gsteroenterology:July 06, 2021 DOI:https://doi.org/10.1053/j.gastro.2021.07.002

Background & Aims
Vitamin D has been implicated in colorectal cancer (CRC) pathogenesis, but it remains unknown whether total vitamin D intake is associated with early-onset CRC and precursors diagnosed before age 50.

Methods
We prospectively examined the association between total vitamin D intake and risks of early-onset CRC and precursors among women enrolled in the Nurses’ Health Study II. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset CRC were estimated with Cox proportional hazards model. Multivariable-adjusted odds ratios (ORs) and 95% CIs for early-onset conventional adenoma and serrated polyp were estimated with logistic regression model.

Results
We documented 111 incident cases of early-onset CRC during 1,250,560 person-years of follow-up (1991 to 2015). Higher total vitamin D intake was significantly associated with a reduced risk of early-onset CRC (HR for ≥450 IU/day vs <300 IU/day, 0.49; 95% CI, 0.26–0.93; P for trend = .01).
The HR per 400 IU/day increase was 0.46 (95% CI, 0.26–0.83). The inverse association was significant and appeared more evident for dietary sources of vitamin D (HR per 400 IU/day increase, 0.34; 95% CI, 0.15–0.79) than supplemental vitamin D (HR per 400 IU/day increase, 0.77; 95% CI, 0.37–1.62). For CRC precursors, the ORs per 400 IU/day increase were 0.76 (95% CI, 0.65–0.88) for conventional adenoma (n = 1,439) and 0.85 (95% CI, 0.75–0.97) for serrated polyp (n = 1,878).

Conclusions
In a cohort of younger women, higher total vitamin D intake was associated with decreased risks of early-onset CRC and precursors.
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References include

• Global patterns and trends in colorectal cancer incidence in young adults.
• Colorectal cancer incidence patterns in the United States, 1974–2013.
• Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975–2010.
• Colorectal cancer in the young: epidemiology, prevention, management.
• Prevalence and spectrum of germline cancer susceptibility gene mutations among patients with early-onset colorectal cancer.
• Early-onset colorectal cancer in young individuals.
• Clinical and molecular features of young-onset colorectal cancer.
• Sedentary behaviors, TV viewing time, and risk of young-onset colorectal cancer.
• Association of obesity with risk of early-onset colorectal cancer among women.
• Plasma vitamin D metabolites and risk of colorectal cancer in women.
• A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer.

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Young People’s Gut Bacteria May Drive Colorectal Cancer Risk - June 2024

MD Edge

• "The cells of young people with colorectal cancer also appeared to have aged more quickly — by 15 years on average — than a person’s actual age. That’s unusual, because older people with colorectal cancer don’t have the same boost in cellular aging."
• " In 2019, one in five colorectal cancer cases were among people younger than 55. That’s up from 1 in 10 in 1995, which means the rate has doubled in less than 30 years."
• "This latest study aligned with previous findings that link bacteria called Fusobacterium to colorectal cancer. It’s not unusual for Fusobacterium to be present in a person’s mouth, but it is more likely to be found in the intestines of colorectal cancer patients, compared with those of healthy people. One study even found that people with colorectal cancer were five times more likely to have Fusobacterium in their stool, compared with healthy people."

Their conclusion - test for colorectal cancer annually. Why not just take Vitamin D (<1 cent/day)?

400 IU daily was found to reduce early Colorectal cancer by 2X (see study on this page)
Suspect that 1,600 IU daily would reduce Colorectal Cancer by 4X
Taking 50,000 IU capsule just ONCE A MONTH = 1600 IU average) is anticipated to also get a 4 X reduction
Cost of a 50,000 IU capsule is less than 1 cent per day (20 cents per month)