Periodontitis reduced by Vitamin D - many studies

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26+ VitaminDWiki pages with PERIODON... in the title

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3% less likely to get Peridontitis for every 1 ng more vitamin D - April 2021

Association between Periodontitis and Vitamin D Status: A case-control study
Saudi Journal of Biological Sciences https://doi.org/10.1016/j.sjbs.2021.04.006
AbdullahAli H. AlzahraniaRaed A.AlharbibMohammedSarhan A. AlzahranicMohammed A.SindidGhaliaShamlaneFaisal A.AlzahranifMohammad A.AlbanghaligAbdulmajeedAbdulghani A Sindih

Vitamin D deficiency and periodontitis are commonly prevalent among Saudi adults. However, the association between periodontitis and vitamin D status has not been well documented. This study aims to examine the association between periodontitis and vitamin D status among adults in the Albaha region of Saudi Arabia. A case-control study of 123 Saudi adults was conducted; 60 had severe or moderate periodontitis, and 63 were periodontally healthy. Data was collected by an online self-reported sociodemographic questionnaire. All participants then underwent a full periodontal examination. Blood samples were also provided to assess participants’ vitamin D statuses through serum levels of 25-hydroxyvitamin D (25(OH)D). A total of 60 cases and 63 controls matched for BMI (30.2 ± 4.86 kg/m2), age (40.01 ± 7.73 years), and sex (46.3% and 53.7% male and female, respectively) participated in the study. Mean levels of 25(OH)D were significantly lower in periodontitis participants than in controls (25.03 ± 8.55 ng/ml, 29.19 ± 12.82 ng/ml, p = 0.037, respectively).
Lower odds of periodontitis were detected per unit of 25(OH)D level (OR 0.964, 95% CI; 0.931-0.999, p = 0.043). In conclusion, periodontitis is significantly associated with deficient and insufficient levels of vitamin D among Saudi adults in the Albaha region. Future longitudinal research with a larger sample size may be suggested to confirm these results.
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Risk of COVID-19 death 8X more likely if have peridontitis - Feb 2021

NEW STUDY LINKS PERIODONTITIS AND COVID‐19 COMPLICATIONS
"...After adjusting for potential confounders, periodontitis was associated with COVID‐19 complication including

• death (OR = 8.81, 95% CI 1.00–77.7),
• ICU admission (OR = 3.54, 95% CI 1.39–9.05) and
• need for assisted ventilation (OR = 4.57, 95% CI 1.19–17.4)."

DOI: https://doi.org/10.1111/jcpe.13435 FREE PDF

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Hypothesis: COVID-19 & Periodontitis: The cytokine connection - Nov 2020

https://doi.org/10.1016/j.mehy.2020.109908 FREE PDF

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The Importance of Vitamin D for Periodontal Tissues - March 2021

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Vitamin D and Periodontitis (no conclusion) - meta-analysis Aug 2020

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis
Nutrients doi: 10.3390/nu12082177
Vanessa Machado,1,2,*† Sofia Lobo,1,† Luís Proença,3 José João Mendes,2 and João Botelho1,2

To explore the vitamin D levels of periodontitis patients in comparison with periodontally healthy ones, and to assess the influence of vitamin D supplementation as an adjunctive during nonsurgical periodontal treatment (NSPT). Five databases (Pubmed, Embase, Scholar, Web of Sciences, and Cochrane Library) were searched until May 2020. Mean difference (MD) meta-analysis with corresponding 95% confidence interval (95% CI) and sensitivity tests via meta-regression were used. We followed Strength of Recommendation Taxonomy (SORT) to appraise the strength and quality of the evidence. Sixteen articles were included, fourteen case-control and two intervention studies, all reporting 25-hydroxyvitamin D (25(OH)D) levels. Compared with the healthy controls, the circulating 25(OH)D levels were significantly lower in chronic periodontitis patients (pooled MD = −6.80, 95% CI: −10.59 to −3.02). Subgroup analysis revealed differences among 25(OH)D measurements, with liquid chromatography-mass spectrometry being the most homogeneous method (pooled MD = −2.05, 95% CI: −3.40 to −0.71). Salivary levels of 25(OH)D showed no differences between groups. Due to the low number of studies, conclusions on aggressive periodontitis and in the effect of vitamin D supplementation after NSPT were not possible to ascribe. Compared with healthy controls, 25(OH)D serum levels are significantly lower in chronic periodontitis patients, with an overall SORT A recommendation. Future studies are needed to clarify the effect of vitamin D supplementation and the biological mechanisms linking vitamin D to the periodontium.

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See also VitaminDWiki

• Dental category listing has 116 items along with related searches
• Inflammation category listing has 173 items along with related searches
• Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016
• Inflammation is associated with low vitamin D in at least 15 diseases – April 2020
• Note: The founder of VitaminDWiki put Topical Vitamin D daily on his inflammed gums, which became healthy in about 2 weeks
  • Topical vitamin D works wonders for a variety of skin conditions
  • Topical application appears to get >100X higher concentration to that portion of the skin than the same amount taken orally
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • Peridontitis adds another - which might have the largest increase in COVID-19 risk factor

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What are some of the diseases linked to periodontitis - Asked Perplexity AI March 2024

Periodontitis has been linked to a variety of systemic diseases, as indicated by multiple studies. The diseases associated with periodontitis include:

• Diabetes: Individuals with diabetes are more likely to have periodontal disease, and periodontal disease may make it more difficult for those with diabetes to control their blood sugar, potentially increasing the risk for diabetic complications
• Heart Disease: Research suggests that periodontal disease may increase the risk of heart disease, possibly due to inflammation caused by periodontal disease. It can also exacerbate existing heart conditions
• Respiratory Disease: Bacteria from periodontal disease can be aspirated into the lungs, contributing to respiratory diseases such as pneumonia. Periodontitis has also been linked with Chronic Obstructive Pulmonary Disease (COPD), although evidence for a direct link remains preliminary.
• Cancer: Studies have found that men with gum disease were more likely to develop kidney cancer, pancreatic cancer, and blood cancers
• Alzheimer’s Disease: There is evidence suggesting a connection between the bacteria associated with periodontal disease and the progression of Alzheimer’s disease
  Adverse Pregnancy Outcomes: Periodontitis is related to maternal infection, preterm birth, low birth weight, and preeclampsia
• Chronic Kidney Disease (CKD): CKD has been associated with periodontitis in several studies, though the complex pathogenesis of CKD and its close linkage with other conditions like diabetes makes it difficult to establish a direct link
• Rheumatoid Arthritis (RA): Early studies reported an association between periodontitis and RA, but current evidence for periodontitis as a risk factor for developing RA is limited
• Cognitive Impairment: There is limited evidence from current studies for an association between periodontitis and cognitive impairment, which can precede dementia of the Alzheimer's disease type
• Obesity and Metabolic Syndrome: While obesity is associated with an increased risk of periodontitis, the evidence for a direct link between periodontitis and metabolic syndrome is not well-established

These associations are not necessarily causal, but they do suggest that periodontal disease may contribute to the progression or severity of these systemic conditions. The mechanisms underlying these associations are complex and involve both direct effects of oral pathogens and indirect effects related to inflammation and immune responses
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