One autoimmune disease lowers vitamin D, a second AI disease does not lower it further – Jan 2015

Vitamin D and autoimmunity: what happens in autoimmune polyendocrine syndromes?

Journal of Endocrinological Investigation, January 2015
G. Bellastella giuseppe.bellastella at unina2.it , M. I. Maiorino, M. Petrizzo, A. De Bellis, A. Capuano, K. Esposito, D. Giugliano
1. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Piazza L. Miraglia 2, 80138, Naples, Italy
2. IOS and Coleman Medicina Futura Medical Center, Centro Direzionale, Naples, Italy
3. Department of Cardio-Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
4. Department of Experimental Medicine, Second University of Naples, Naples, Italy
5. Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy

Purpose
To evaluate the Vitamin D status of patients with a single autoimmune disease and of patients with several autoimmune diseases.

Methods
We enrolled 35 patients with isolated type 1 diabetes mellitus (T1DM), 60 with autoimmune polyendocrine syndromes (APS) including T1DM and 72 control subjects. Among patients with APS, 10 were classified as type 2 (Addison’s disease + T1DM), whereas the other 50 as type 3 (autoimmune thyroid disease + T1DM + other autoimmune diseases). Vitamin D (25-OHD) levels were assessed by a chemiluminescent immunoassay in all patients and controls on samples drawn in the morning of the same months.

Results
Both groups of APS and T1DM patients showed 25-OHD levels significantly lower than healthy controls (p < 0.001 for both vs controls), without any significant difference between the two groups (p = 0.80). The highest prevalence of vitamin D deficiency (values <20 ng/ml) was observed in APS type 3 subgroup (8 out of 50 patients, 16 %).

Conclusions
Patients with APS present reduced vitamin D circulating levels, but the vitamin D status is not different between patients with single or multiple autoimmune diseases. The kind of autoimmune disease, rather than the association of several autoimmune diseases, may influence negatively the levels of vitamin D. Further prospective studies are needed to clarify if impaired vitamin D level is a causal factor in the pathogenesis of autoimmune diseases or a consequence of them.

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See also VitaminDWiki

• Autoimmune category listing with associated searches
• Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
• Review of Autoimmune diseases, solar radiation and vitamin D – Schwalfenberg 2012
• How UVB reduces autoimmune diseases such as Multiple Sclerosis – April 2014
• Diseases that may be related via low vitamin D which has the following chart
  
• 3 to 55 X more likely to have these health problems if low Vitamin D has the following