Increase vitamin D levels if they are low - April 2023

A Scoping Review of Vitamin D for Nonskeletal Health: A Framework for Evidence-Based Clinical Practice

Clin Ther. 2023 Apr 18;S0149-2918(23)00127-3. doi: 10.1016/j.clinthera.2023.03.016   PDF is behind a paywall
Heitor O Santos 1, Carlos Eduardo E Martins 2, Scott C Forbes 3, Felipe M Delpino 4

Background: Low serum 25-hydroxy-vitamin D [25(OH)D] levels are prevalent worldwide. Although the benefits of vitamin D supplementation have focused on skeletal disorders (eg, rickets, osteomalacia, osteoporosis), emerging evidence for nonskeletal health merits further discussion.

Purpose: The purpose of this review was to critically examine the vitamin D supplementation literature pertaining to nonskeletal health to help guide clinicians.

Methods: A scoping review that included observational studies and randomized clinical trials (RCTs) was performed. Evidence from meta-analyses and individual RCTs are discussed, and controversies and future directions are considered.

Findings: 25(OH)D deficiency is a ubiquitous condition associated with multiple nonskeletal diseases, including

• cardiometabolic (heart disease, diabetes, and kidney disease),
• immune (HIV/AIDS and cancer),
• lung (from traditional chronic disorders to coronavirus disease 2019), and
• gut diseases.

Vitamin D deficiency also affects health across the life span (children, pregnant, and elderly), mental illness, and reproduction in both men and women.
In contrast, vitamin D supplementation does not necessarily improve major medical outcomes, even when low 25(OH)D levels are treated. Screening for 25(OH)D status remains an important practice, primarily for high-risk patients (eg, elderly, women with osteoporosis, people with low exposure to sunlight). It is reasonable to supplement with vitamin D to treat 25(OH)D deficiency, such that if beneficial nonskeletal health occurs, this may be considered as a coadjutant instead of the central tenet of the disease. Furthermore, optimizing dosing regimens is an important clinical consideration.

Implications: Although 25(OH)D deficiency is prevalent in nonskeletal diseases, there is no uniform evidence that vitamin D supplementation improves major medical outcomes, even when low 25(OH)D levels are corrected. Findings from RCTs warrant caution due to possible selection bias. Overall, vitamin D supplementation must be guided by circulating levels as a reasonable medical practice to correct 25(OH)D deficiency.

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Some studies on restoring Vitamin D

• Restore your Vitamin D levels before surgery (Gastric Cancer in this case) - Jan 2023
• Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
• Restore in just days, not months

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6 times to 55 times more likely to get the following health problems if Vitamin D deficient

• Many health problems associated with low vitamin D
       click to read the studies
• 55 X more likely to have bone fracture requiring surgery
• 30 X more likely for COPD becoming suddenly worse
• 25 X more likely to have senior moment
• 23 X more likely to have vertigo
• 19 X more likely to get dementia
• 17 X more likely to have muscle inflammation
• 14 X more likely to die after first cardiovascular event
• 14 X more likely for dark-skinned children to get T1 diabetes
• 12 X more likely to die from elderly pneumonia
• 11 X more likely to be allergic to peanuts
• 10 X more reactions to flu vaccine
• 10 X more likely for stroke patients to become depressed
• 9 X more likely to have Gastric Cancer
• 8 X more likely to have Autoimmune Hepatitis
• 8 X more likely for alcoholic to have Alcoholic liver disease
• 8 X more likely to get lupus
• 7 X more likely to have low birth weight infant
• 7 X more likely for pregnant teen to have anemia
• 7 X more likely to have leg pain
• 7 X increased chance of death from coronary artery disease
• 6.5 X more likely for infant to be Small for Gestational Age
• 6 X worse outcome following Sudden cardiac arrest
• 6 X more likely to get hip fracture after stroke
• 6 X more likely to die after coronary bypass
• 6 X more likely to have allergic rhinitis
• 6 X more likely to get diabetes if abdominal obese
• 6 X more likely to get cancer in children

CLICK HERE for entire 3X to 55X list for more information

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Restoring vitamin D will prevent many subsequent diseases

click here for details

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VitaminDWik – Optimum category contains

The RDA is barely enough for the bones to survive.
   Need an optimal level for the body to thrive

99 items in Optimum Vitamin D category

Example pages

• Is 50 ng of vitamin D too high, just right, or not enough
• More than 30 ng of vitamin D is needed for many diseases - Feb 2022 has

• Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
• Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015
• Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis March 2019
• Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
• 4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022
• Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
• Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
• Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
• Hypothesis by VitaminDWiki – Vitamin D levels are no longer limited by evolution
• VitaminDWiki pages with HIGH-DOSE in title 57 as of Feb 2022