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Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014

Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk.

Tumour Biol. 2014 Jan 10.
Xu Y, He B, Pan Y, Deng Q, Sun H, Li R, Gao T, Song G, Wang S.
Central Laboratory of Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, China.

See also VitaminDWiki

Vitamin D Receptor category has the following

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B		 Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?		Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient		Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
All items in both Genes and Cancer categories (this does not display items in the Cancer sub-categories)

All items in both Genes and Breast Cancer categories

The vitamin D receptor (VDR) can influence cancer susceptibility through binding to vitamin D. However, the previous studies were contradictory. Therefore this meta-analysis was conducted to clarify the association between VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) and cancer risk. One hundred twenty-six studies were enrolled through PubMed.

  • For VDR BsmI polymorphism, significantly increased cancer risks were observed in the overall analysis.
  • In the further stratified analysis, increased risks were observed in colorectal and skin cancer, especially in Caucasian population.

However, no significant associations were observed in other VDR polymorphisms in the overall analysis.
In the further subgroup analysis,

  • increased risks were found in oral, breast, and basal cell cancer while
  • decreased risk was found in prostate cancer in t allele carriers of TaqI polymorphism.
  • For VDR FokI polymorphism,
    increased risks were found in ovarian and skin cancer while
    decreased risk in glioma in f allele carriers.
  • For VDR ApaI polymorphism,
    increased risk was observed in basal cell cancer, especially in Asian population in a allele carriers.

In conclusion, these results indicated that

  • b allele of BamI polymorphism was a
    risk factor for cancer susceptibility.
  • Meanwhile, t allele of TaqI polymorphism was a
    risk factor for oral, breast, and basal cell cancer and a
    protective factor for prostate cancer.
  • Moreover, f allele of FokI polymorphism was a
    risk factor for ovarian and skin cancer and a protective factor for glioma.
  • Finally, a allele of ApaI polymorphism was a
    risk factor for basal cell cancer in Asian population.


PMID: 24408013

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Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014        
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