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Vitamin D and neurocognitive function – Holick Oct 2022

Vitamin D and neurocognitive function

Clinical Interventions in Aging, , 559-568, DOI: 10.2147/CIA.S51785 https://doi.org/10.2147/CIA.S51785
Mathias Schlögl & Michael F Holick
'University Center for Medicine of Aging Basel, University of Basel, Basel, Switzerland; 2Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA

Video abstract
In recent years, emerging evidence has linked vitamin D not only to its known effects on calcium and bone metabolism, but also to many chronic illnesses involving neurocognitive decline. The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency. The older population is at an especially high risk for vitamin D deficiency due to the decreased cutaneous synthesis and dietary intake of vitamin D. Recent studies have confirmed an association between cognitive impairment, dementia, and vitamin D deficiency. There is a need for well-designed randomized trials to assess the benefits of vitamin D and lifestyle interventions in persons with mild cognitive impairment and dementia.

PDF Table of Contents includes:

Vitamin D receptor in the brain
Vitamin D and aging
Malnutrition in the elderly
Prevalence of vitamin D deficiency
Vitamin D and neurocognitive functioning
Vitamin D and mild cognitive impairment
Vitamin D, Alzheimer’s disease, and vascular dementia

Appears to be very similar to: Vitamin D and neurocognitive function – Holick April 2014

49 VitaminDWiki pages with HOLICK in title (as of Oct 2022)

This list is automatically updated

Items found: 57
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VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains

VitaminDWiki - Cognitive category cpntains

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

391 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (8 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (52 studies), Intervention (20 studies), Meta-analyses (22 studies), Depression (24 studies), Parkinson's (24 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392

94 VitaminDWiki pages with BRAIN in title (as of Oct 2022)

This list is automatically updated

Items found: 113
Title Modified
Traumatic Brain Injuries routinely treated by Vitamin D, Omega-3, Progesterone and Gluatmine 15 May, 2019
Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019 13 May, 2019
Resveratrol and Brain Mitochondria: a Review – March 2018 28 Apr, 2019
Off topic: Limbic System and Brain can both be retrained (plasticity) – March 2019 17 Mar, 2019
Hypothesis – Brain plasticity improved by Vitamin D – Feb 2019 20 Feb, 2019
Standard Omega-3 not get past blood-brain barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018 25 Dec, 2018
Omega-3 is important for Brain Health during all phases of life – Aug 2018 08 Dec, 2018
Poor blood-brain barrier following stroke if low vitamin D (in rats) – RCT Feb 2019 01 Dec, 2018
Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018 23 Nov, 2018
Perhaps drugs such as inhaled vitamin D can get directly to the brain – March 2018 19 Nov, 2018
Brain injury disability associated with lower vitamin D – Oct 2018 20 Oct, 2018
Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010 03 Oct, 2018
Autistics and Schizophrenics have 3X lower Vitamin B12 levels in the brain – Jan 2016 01 Oct, 2018
The Role of Vitamin D in Brain Health: A Mini Literature Review – Sept 2018 15 Sep, 2018
Brain is helped by Omega-3 during all phases of life – Aug 2018 21 Aug, 2018
Following strokes, brain scans (MRI) 3X worse in those having low vitamin D – July 2018 25 Jul, 2018
Smaller brains (Intracranial Volume) associated with lower vitamin D – July 2018 21 Jul, 2018
Omega-3: An Intelligent Decision for Brain Nutrition (book chapter) April 2018 24 Apr, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
Woolly mammoth brains, like mammal brains, were a good source of Omega-3 – March 2018 07 Apr, 2018
ADHD 4 year-olds – smaller brain regions proportional to ADHD severity – March 2018 26 Mar, 2018
60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018 22 Feb, 2018
Brain Tumor surgery – will previous injection of 300,000 IU Vitamin D help – RCT 2018 29 Dec, 2017
Off topic: Brain Plasticity (best way to exercise your brain) – Interview Dec 2012 08 Dec, 2017
Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 08 Dec, 2017
Nerve growth and survival depends on BDNF (Brain-Derived Neurotrophic Factor), which is associated with Vitamin D 19 Nov, 2017
Brain may deal with all forms of Vitamin D (rat brain) – Sept 2017 06 Nov, 2017
Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017 10 Oct, 2017
Lymphatic system discovered in brain (what about Multiple Sclerosis, Alzheimer’s, Omega-3 and Vitamin D) – Oct 2017 07 Oct, 2017
Active form of vitamin D directly protects the blood–brain barrier in multiple sclerosis – Aug 2017 26 Aug, 2017
300,000 IU Vitamin D injection before brain tumor surgery – RCT to finish Dec 2017 20 Aug, 2017
Mild Traumatic Brain Injury reduced by Vitamin D – May 2014 07 Aug, 2017
Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017 18 Mar, 2017
Sustained brain attention appears to vary with vitamin D levels – March 2016 21 Jan, 2017
Glioma (brain, spinal cancer) 40 percent less likely if male vitamin D levels were high 15 years earlier – Aug 2015 25 Dec, 2016
Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016 06 Dec, 2016
Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 11 Sep, 2016
Zika causes brain problems in adult (mice) having poor immune systems– Nov 2016 22 Aug, 2016
Magnesium L-Threonate – tiny amount more bioavailable to brain but far more expensive– June 2016 16 May, 2016
Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014 01 May, 2016
Fructose altered hundreds of brain genes (in rats) unless also take Omega-3 – April 2016 01 May, 2016
High-fructose diet slows recovery from brain injury - TBI, rats - Oct 2015 01 May, 2016
Benefits of Omega-3 on brain development 30 Apr, 2016
Football Brain injuries prevented by Omega-3 – RCT Jan 2016 08 Feb, 2016
Traumatic Brain Injury in military - vitamin D - 2014 08 Feb, 2016
Magnesium may be an important way to treat brain trauma 12 Oct, 2015
Less vitamin D, bigger brain - humans and animals - Jan 2015 11 Aug, 2015
Cognitively impaired brain atrophy was slowed 40 percent by Omega-3 and B vitamins – RCT July 2015 14 Jul, 2015
Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014 31 May, 2015
Parkinsons' disease and MRI white matter in brain 25 Feb, 2015
Brains of seniors had 60 percent more white matter abnormalities if low vitamin D – March 2015 25 Feb, 2015
Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 03 Jan, 2015
Vitamin D improved brains in aging rats – Sept 2014 03 Oct, 2014
33 percent more white matter abnormality in brain (periventricular WMA) if low vitamin D – July 2014 15 Jul, 2014
Hypothesis: Chemo brain and other cognitive impairements are associated with low vitamin D 09 Jul, 2014
Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013 05 May, 2014
Low vitamin D is associated with larger brain – Feb 2014 16 Feb, 2014
Low vitamin D is bad for the rat brain (and probably human brain) – Dec 2013 19 Jan, 2014
Low vitamin D associated with brain atrophy in MS – April 2010 19 Jan, 2014
Brain lesions might be associated with vitamin D deficiency – March 2012 19 Jan, 2014
Autism has different causes but same inflammation in brain in half of autistics – May 2011 13 Jul, 2013
Parkinson disease 2X more likely after brain injury – which usually reduces vitamin D – Nov 2012 13 Nov, 2012
If less than 20 ng then 2X more likely to be fatigued after brain injury - April 2010 05 Nov, 2011
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VitaminDWiki - 16 studies in both Cognitive and Vitamin D Receptor categories

This list is automatically updated

It appears that more Vitamin D gets to the brain when it is inhaled thru the nose

Study References
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Vitamin D and neurocognitive function – Holick Oct 2022        
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