- Vitamin D: A key player in COVID-19 immunity and lessons from the pandemic to combat immune-evasive variants
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Vitamin D: A key player in COVID-19 immunity and lessons from the pandemic to combat immune-evasive variants
Inflammopharmacology October 2024 https://doi.org/10.1007/s10787-024-01578-w
Hussein Sabit, Shaimaa Abdel-Ghany, Mahmoud S. Abdallah, Osama Abul-Maaty, Ahmed I. Khoder, Nabil A. Shoman, Mohamed Sameh Farrag, Pavel Martasek, Ayman M. Noreddin & Mahmoud Nazih30,000 Vitamin D publications on COVID
Table of Contents
As of the 7th of July 2024, 775,754,322 confirmed cases of COVID-19, including 7,053,902 deaths worldwide, had been reported to the WHO (World Health Organization). Nevertheless, untill the 15th of July 2024, a total of 13,578,710,228 vaccine doses had been administered, with almost no country spared from COVID-19 attacks. The pathophysiology of this virus is complicated, and several symptoms require a deep understanding of the actual mechanisms. It is unclear why some patients develop severe symptoms while others do not, although literature suggests a role for vitamin D. Vitamin D plays a crucial role in the infection or in ameliorating the severity of symptoms. The mechanism of action of vitamin D and vitamin D deficiency (VDD) is well understood. VDD is associated with increased hospitalization of severely ill patients and increased levels of COVID-19-caused mortality. Recent studies suggest that vitamin D levels and genetic variations in the vitamin D receptor (VDR) gene significantly impact the severity and outcomes of COVID-19, especially in the infections caused by Delta and Omicron variants. Furthermore, VDD causes immune system dysregulation upon infection with SARS-CoV-2, indicating that vitamin D sufficiency is crucial in fighting against COVID-19 infection. The therapeutic effect of vitamin D raises interest in its potential role as a prophylactic and treatment adjunct. We evaluate the immunomodulatory effects of vitamin D and its ability to enhance the efficacy of new antiviral drugs like molnupiravir and paxlovid against SARS-CoV-2. This review discusses the role of vitamin D sufficiency and VDD in COVID-19 initiation and progression, emphasizing the molecular mechanisms by which vitamin D exerts its actions as a proactive step for the next pandemic. However, there is still no clear evidence of vitamin D’s impact on prevention and treatment, leading to contradictory findings. Therefore, large-scale randomized trials are required to reach a definitive conclusion. A bibliometric analysis of publications related to vitamin D, immunity, and COVID-19 revealed a significant increase in research activity in this area, particularly in 2020–2024, underscoring the growing recognition of vitamin D’s potential role in the context of the pandemic.
 Download the PDF from VitaminDWikiClipped from PDF: VDR variants and SARS-cov-2 variants
The role of vitamin D in influencing the severity and outcomes of COVID-19 infection has been an area of active investigation. Recent studies have shed light on the potential interactions between vitamin D status and the emergence of SARS-CoV-2 variants. A longitudinal cohort study on the Omicron BA.2 subvariant in children found that those with vitamin D insufficiency had worse clinical outcomes than those with sufficient vitamin D levels (Peng et al. 2022). Mamurova et al. discovered a significant link between variations in the VDR gene and susceptibility to SARS-CoV-2 variants (Mamurova et al. 2023). This connection implies that genetic differences in VDR might contribute to the varying responses seen among different SARS-CoV-2 strains.
Mamurova B, Akan G, Mogol E, Turgay A, Tuncel G, Evren EU et al (2023) Strong association between vitamin D receptor gene and severe acute respiratory syndrome coronavirus 2 infectious variants. Glob Med Genet 10(01):27–33
Study was reviewed by Dr. Campbell - Oct 23, 2024
VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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VitaminDWiki – COVID variants protect themselves by deactivating different VDR variants– March 2023 37+ studies
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Vitamin D preventing and treating COVID - 30,000 publications – Oct 2024415 visitors, last modified 24 Oct, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 21887 Annual publications.webp admin 20 Oct, 2024 11.28 Kb 113 21886 Key player Toc.webp admin 20 Oct, 2024 22.76 Kb 60 21885 D A key player in COVID_CompressPdf.pdf admin 20 Oct, 2024 806.10 Kb 19 -
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