- The Role of Vitamin D in Reducing the Risk of Metabolic Disturbances That Cause Cardiovascular Diseases
- VitaminDwiki – Cardiovascular category contains
- VitaminDwiki – Metabolic Syndrome contains
- Metabolic Syndrome Associations with 12 other categories
- VitaminDWiki – Overview Diabetes and vitamin D contains
- VitaminDWiki – Diabetes category contains
- VitaminDWiki – Overview Obesity and Vitamin D contains
- VutaminDWiki - Hypertension category contains
- VitaminDWiki - The risk of 44+ diseases at least double with poor Vitamin D Receptor
- VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
The Role of Vitamin D in Reducing the Risk of Metabolic Disturbances That Cause Cardiovascular Diseases
J. Cardiovasc. Dev. Dis. 2023, 10(5), 209; https://doi.org/10.3390/jcdd10050209
by Ziad H. Al-Oanzi 1,*ORCID,Fawaz O. Alenazy 1ORCID,Hassan H. Alhassan 1ORCID,Yasir Alruwaili 1,Abdulaziz I. Alessa 2,Nouf B. Alfarm 2,Maha O. Alanazi 2 andSarah I. Alghofaili 2
1 Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia
2 Department of Pharmacy, Prince Sultan Cardiac Center, Riyadh 11159, Saudi Arabia
Among the most common problems facing public health today is a lack of vitamin D, which plays a role in the physiological processes of chronic illness conditions.
Vitamin D deficiency in metabolic disorders has primary effects on
- osteoporosis,
- obesity,
- hypertension,
- diabetes, and
- cardiovascular disease (CVD).
Vitamin D acts as a “co-hormone” in the various tissues of the body, and it has been found that vitamin D receptors (VDR) are present on all cell types, suggesting that vitamin D has a wide range of effects on most cells.
Recently, there has been a surge in interest in assessing its roles. Vitamin D insufficiency increases the risk of diabetes because it lowers insulin sensitivity, and also raises the risk of obesity and CVD because of its effect on the body’s lipid profile, particularly in terms of the prevalence of dangerously high levels of low-density lipoproteins (LDL).
Furthermore, vitamin D insufficiency is often related to CVD and connected risk factors, highlighting the need to know vitamin D’s functions in relation to metabolic syndrome and related processes. Through looking at previous studies, this paper explains why vitamin D is important, how deficiency is related to risk factors for metabolic syndrome through different mechanisms, and how deficiency affects CVD.
Download the PDF from VitaminDWiki
VitaminDwiki – Cardiovascular category contains
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
VitaminDwiki – Metabolic Syndrome contains
See also
- Overview Metabolic Syndrome and vitamin D
- Overview Diabetes and vitamin D
- Overview Obesity and Vitamin D
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Arteries and Atherosclerosis and Vitamin D - many studies
- Metabolic Syndrome risk decreases by 20 percent with each 10 ng increase in Vitamin D - April 2021
- Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
- Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
- Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
- Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
- Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
- Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
Metabolic Syndrome Associations with 12 other categories
Obesity 19; Diabetes 15; Cardiovascular 12; Magnesium 8; Seniors 8; Women 5; 5; Hypertension 5; Intervention 5; Omega-3 4; Youth 4; Meta-analysis 4
VitaminDWiki – Overview Diabetes and vitamin D contains
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
553 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 57 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 30 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
VitaminDWiki – Diabetes category contains
553 items In Diabetes category 34+ Prediabetes studies 64+ Type 1 Diabetes studies see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has204 items along with related searches
VitaminDWiki – Overview Obesity and Vitamin D contains
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc. - Obesity category has
442 items See also: Weight loss and Vitamin D - many studies Child Obesity and Vitamin D - many studies Obesity, Virus, and Vitamin D - many studies
Obese need more Vitamin D- Normal weight Obese (50 ng = 125 nanomole)
VutaminDWiki - Hypertension category contains
166 items in the category HYPERTENSION see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies- Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
- Hypertension risk reduced 4X if adequate level of Vitamin D – July 2024
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
- Magnesium reduces hypertension - FDA allows claim - Jan 2022
- Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
- High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
- Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
- Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018
VitaminDWiki - The risk of 44+ diseases at least double with poor Vitamin D Receptor
VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
Vitamin D both reduces CVD directly and reduces metabolic problems that cause CVD – May 2023Printer Friendly Follow this page for updates12154 visitors, last modified 26 May, 2023, This page is in the following categories (# of items in each category)