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Vitamin D Health problems can run in families (epigenetics, they miss other reasons) – June 2023)


Effect of epigenetics on vitamin D levels: a systematic review until December 2020

Arch Public Health. 2023 Jun 15;81(1):106. doi: 10.1186/s13690-023-01122-2.
Ali Forouhari 1, Motahar Heidari-Beni 2, Shaahin Veisi 3, Parnian Poursafa 4, Roya Kelishadi 5

Background: The association between epigenetic modification of the genes involved in the vitamin D metabolic pathway and vitamin D metabolites' status has been elucidated incompletely. This study aims to review the studies on the mentioned association and create a brighter view of this topic.

Methods: A systematic literature search was conducted in Medline database (PubMed), Scopus, and Web of Science up to the end of November 2020. Original articles which reported the effect of epigenetic alteration-methylation level or its changes-of genes involved in vitamin D regulation on the vitamin D metabolites serum level or its changes were included. The National Institutes of Health (NIH) checklist was used to assess the quality of included articles.

Results: Among 2566 records, nine reports were included in the systematic review according to the inclusion and exclusion criteria. Studies discussed the contribution of methylation status of members of the

  • cytochrome P450 family (CYP2R1, CYP27B1, CYP24A1), and
  • Vitamin D Receptor (VDR) genes to vitamin D level variance.

CYP2R1 methylation status could regulate the contributing factors affecting the vitamin D serum level and predict response to vitamin D supplementation. Studies revealed that impaired methylation of CYP24A1 occurs in response to an increase in serum level of 25-hydroxyvitamin D (25(OH)D). It is reported that the association between methylation levels of CYP2R1, CYP24A1, and VDR genes and 25(OH)D level is not affected by the methyl-donors bioavailability.

Conclusions: The epigenetic modification of the vitamin D-related genes could explain the vitamin D levels variation among populations. Large-scale clinical trials in various ethnicities are suggested to find the effect of epigenetics on vitamin D response variation.

Registration: The systematic review protocol was registered on PROSPERO (registration number: CRD42022306327).
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VitaminDWiki – Genetics category contains

343 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
        especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) DNA and VDR tests - 100 to 200 dollars $100 to $250
    4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
       Genes are good, have enough Magnesium, etc.
    5) Back Pain
       probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
      • The founder of VitaminDWiki took action with clues #3&5

VitaminDwiki - Reasons for low response by vitamin D level in the blood


VitaminDWiki - Health problems that run in families are often associated with low vitamin D

Includes a section "Gene studies of health problems which run in families" - variety of problems


17+ VitaminDWiki pages with EPIGENETICS in the title

This list is automatically updated

Items found: 19
Title Modified
Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024 26 Mar, 2024
Epigenetics and Vitamin D – many studies 23 Oct, 2023
Vitamin D Health problems can run in families (epigenetics, they miss other reasons) – June 2023) 16 Jun, 2023
Vitamin D supplementation is associated with slower epigenetic aging - May 2022 21 Jun, 2022
Epigenetics, vitamin D, and Multiple Sclerosis 15 Jun, 2022
Epigenetics - PDFs and links, with and without Vitamin D 25 Feb, 2021
Epigenetics identified Cervical Cancer 100 percent of time – 2019 23 Dec, 2019
Stressors as a fetus or child can cause health problems in adult (perhaps via epigenetics) – Dec 2017 14 Oct, 2018
Health problems can persist through many generations – Epigenetics and Vitamin D 13 Oct, 2018
Epigenetics meets endocrinology – 2011 13 Oct, 2018
Vitamin D Receptor – environment, genetics and epigenetics – May 2015 13 Oct, 2018
Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016 05 May, 2016
Epigenetics of Multiple Sclerosis – March 2014 06 Sep, 2015
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015
Epigenetics meets endocrinology - 2011 21 Jan, 2015
Hypothesis: Epigenetics, vitamin D, and Multiple Sclerosis – Nov 2012 29 Aug, 2014
Epigenetics of prostate cancer and vitamin D – June 2010 09 Jul, 2013
Lung disease, vitamin D, and epigenetics – Aug 2011 13 Feb, 2012
Epigenetics and vitamin D – June 2010 clips from the web 05 Jun, 2010

VitaminDWiki - (Many reasons why vitamin D deficiency has become epidemic only some of them are genetics

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ID Name Comment Uploaded Size Downloads
19663 Epigenetics.pdf admin 16 Jun, 2023 267.05 Kb 164