- A systematic review and meta-analysis of vitamin D status of patients with severe obesity in various regions worldwide
- VitaminDWiki – Overview Obesity and Vitamin D contains
- VitaminDWiki – Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 contains:
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11 studies in both categories Obesity and Magnesium
A systematic review and meta-analysis of vitamin D status of patients with severe obesity in various regions worldwide
Obes Facts , DOI: 10.1159/000533828 August 28, 2023
Neda Haghighat1, Zahra Sohrabi2, Reza Bagheri3, Marzieh Akbarzadeh2, Zahra Esmaeilnezhad2, Damoon Ashtary- Larky1, Reza Barati-Boldaji2, Morteza Zare2, Masoud Amini1, Seyed Vahid Hosseini4, Alexei Wong5, Hamidreza Foroutan1 forotanh at sums.ac.ir
1 Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Community Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
4 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5 Department of Health and Human Performance, Marymount University, Arlington, VA, United States.Many charts in the PDF do not have good lables
Introduction: Managing nutritional deficiencies is an essential component in the treatment of severe obesity. Vitamin D deficiency is often reported in investigations in severe obese cohorts. However, no prior study has summarized findings on this topic. Consequently, the aim of this systematic review and meta-analysis was to investigate the 25- hydroxyvitamin D [25(OH)D] status in individuals with severe obesity in different regions worldwide. We also evaluated levels of calcium, PTH, and magnesium as secondary outcome measures.Methods: We searched Medline, PubMed, Scopus, the Cochrane Library, and EMBASE for relevant observational studies published in English from 2009 to October 2021. The heterogeneity index among the studies was determined using the Cochran (Q) and I2 tests. Based on the heterogeneity results, the random-effect model was applied to estimate the prevalence of vitamin D deficiency.
Results: We identified 109 eligible observational studies. Overall,
- 59.44% of patients had vitamin D deficiency [25(OH)D <20 ng/ml], whereas
- 26.95% had vitamin D insufficiency [25(OH)D 20-30 ng/ml].
Moreover, the mean 25(OH)D levels was 18.65 ng/ml in 96 studies. The pooled mean estimate of the serum calcium, PTH and magnesium was
- Calcium: 9.26 mg/dl (95% CI: 9.19-9.32, I2=99.7%, p<0.001)
- PTH: 59.24 pg/ml (95% CI: 54.98, 63.51), I2= 99.7%, p < 0.001), and
- magnesium: 0.91 mg/dl (0.84, 0.98, I2= 100.0%, p < 0.001), respectively.
The results of the sub-group analysis indicated that the mean estimates of 25(OH)D was highest in North America [21.71 ng/ml (19.69, 23.74), (I2=97.2%, p<0.001)] and lowest in Southeast Asia [14.93 ng/ml (14.54, 15.33), (I2=0.0%, p = 0.778)].
Conclusion: The results obtained showed a significant prevalence of vitamin D deficiency among severely obese individuals in various geographical regions, whereas the highest and lowest mean estimates were reported for North America and Southeast Asia, respectively.
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VitaminDWiki – Overview Obesity and Vitamin D contains
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc. - Obesity category has
442 items See also: Weight loss and Vitamin D - many studies Child Obesity and Vitamin D - many studies Obesity, Virus, and Vitamin D - many studies
Obese need more Vitamin D
- Normal weight Obese (50 ng = 125 nanomole)
- Normal weight Obese (50 ng = 125 nanomole)
VitaminDWiki – Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 contains:
Fast weight loss by Obese Adults: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
* Vitamin D levels must be above 30ng/ml to help with weight loss
* Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
Note: Magnesium reduces weight loss by itself as well
20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
Vitamin D Receptor activator: 0-30% improved Vitamin D response
Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
His book does not mention Vitamin D nor Adenovirus
VitaminDWiki -
11 studies in both categories Obesity and Magnesium This list is automatically updated
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- More Magnesium needed by obese (Mg Sulfate, women in this case) – RCT Dec 2021
- PTH failed to decrease with Vitamin D if overweight and had low Magnesium – Aug 2019
- Magnesium may help with calorie restriction, ALS, and R-loops in DNA - LEF Oct 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Obesity epidemic: a perfect storm of deficiency of vitamin D, Magnesium, Iodine, etc – May 2012
- Obesity pandemic since 1975 - is it due to Vitamin D, Magnesium, Iodine, adenovirus, or what
- Reasons for low response to vitamin D
- Weight loss and Vitamin D, Calcium, and Magnesium
- Overview Magnesium and vitamin D
Severe obesity is related to low vitamin D around the world – Aug 20233460 visitors, last modified 29 Aug, 2023,