The Effects of Vitamin D Supplementation during Pregnancy and Maternal Vitamin D Levels on Neonatal Vitamin D Levels and Birth Parameters.
J Matern Fetal Neonatal Med. 2017 May 5:1-16. doi: 10.1080/14767058.2017.1326897. [Epub ahead of print]
Publisher wants $54 for the PDF
Suspect that the Turkish govt provided only 400 IU for the pregnant women
Reminder - World Health Oeganization still recommends ZERO vitamin D while pregnant (as of May 2017)
Healthy pregnancies need lots of vitamin D has the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for details
Problem | Vit. D Reduces | Evidence |
| 0. Chance of not conceiving | 3.4 times | Observe |
| 1. Miscarriage | 2.5 times | Observe |
| 2. Pre-eclampsia | 3.6 times | RCT |
| 3. Gestational Diabetes | 3 times | RCT |
| 4. Good 2nd trimester sleep quality | 3.5 times | Observe |
| 5. Premature birth | 2 times | RCT |
| 6. C-section - unplanned | 1.6 times | Observe |
| Stillbirth - OMEGA-3 | 4 times | RCT - Omega-3 |
| 7. Depression AFTER pregnancy | 1.4 times | RCT |
| 8. Small for Gestational Age | 1.6 times | meta-analysis |
| 9. Infant height, weight, head size within normal limits | RCT | |
| 10. Childhood Wheezing | 1.3 times | RCT |
| 11. Additional child is Autistic | 4 times | Intervention |
| 12.Young adult Multiple Sclerosis | 1.9 times | Observe |
| 13. Preeclampsia in young adult | 3.5 times | RCT |
| 14. Good motor skills @ age 3 | 1.4 times | Observe |
| 15. Childhood Mite allergy | 5 times | RCT |
| 16. Childhood Respiratory Tract visits | 2.5 times | RCT |
RCT = Randomized Controlled Trial
Kılıcaslan AÖ1, Kutlu R2, Kilinc I3, Ozberk DI2.
1 Karatay Fetih Family Health Center , Konya , Turkey.
2 Necmettin Erbakan University, Meram Medicine Faculty, Dept. of Family Medicine , Konya , Turkey.
3 Necmettin Erbakan University, Meram Medicine Faculty, Dept. of Medical Biochemistry , Konya , Turkey.
OBJECTIVE:
The current study aimed to measure the levels of vitamin 25(OH)D in pregnant women and in the umbilical cord blood of newborns and to evaluate the association of vitamin D levels with birth parameters.
METHODS:
This cross-sectional analytic investigation was performed in 100 pregnant women at term and in 100 newborns born to these mothers. Plasma vitamin D level was measured and birth parameters of the babies were recorded.
RESULTS:
Mean vitamin D levels in pregnant women and cord blood were 11.39±6.24 ng/ml and 8.00± 4.95ng/ml, respectively. Vitamin D levels were found to be higher in the women who had received vitamin D support during pregnancy (p < 0.001).
- Height (p = 0.004),
- head circumference (p = 0.003), and
- chest circumference (p = 0.005)
of newborns born to mothers who had received vitamin D support were higher compared to non-receivers. Maternal vitamin D deficiency (<10ng/ml) and insufficiency (10-30 ng/ml) was detected in 53.0% and 47.0% of the cases, respectively.
None of the women had sufficient levels of vitamin D.
CONCLUSION:
This study established that vitamin D levels were low in maternal and cord blood in spite of the administration program of Ministry of Health in pregnant women. The importance of vitamin D supplementation should be explained to the pregnant women in each visits.
PMID: 28475394 DOI: 10.1080/14767058.2017.1326897