Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia)
Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C135-C151. doi: 10.1152/ajpcell.00188.2017. Epub 2017 Oct 25.
Michael J Berridge 1
Fertility and Sperm category contains the following summary
See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" etc. in 18 VitaminDWiki titles
Vitamin D greatly improves Fertility
- Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
- In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
- Women were 50X more likely to be fertile if just 1 ng higher level of vitamin D – Nov 2024
- Infertile patients 1.7X more-likely to become pregnant if take Vitamin D – meta-analysis Feb 2023
- Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis Aug 2020
- If diagnosed infertile, more likely to have live birth if Vitamin D fortification – Feb 2020
- Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
- Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
- Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
- Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
- IVF 4X more successful for white women with lots of vitamin D – many studies
Increased male Vitamin D increases fertility
- Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017
- Higher vitamin D results in 22% fewer abnormal sperm (Mendelian analysis) – May 2024
- Conception was 3.7X more likely if the male had a good level of Vitamin D – July 2022
- Far better sperm in fertility clinic if more than 30 ng of Vitamin D - June 2022
- Fertility (sperm) associated with vitamin D – meta-analysis Sept 2019
- Infertility - 71 percent of the time of BOTH partners had less than 20 ng of Vitamin D – Aug 2017
- Male fertility 4 X higher if high Vitamin D – Nov 2015
- Vitamin D somewhat assists reproduction – both the mother and the father – May 2014
Decreased Fertility if decreased Vitamin D Receptor
- Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
- Male Infertility is associated with poor Vitamin D Receptor – July 2021
Autism category in VitaminDWiki starts with
Autism category has - see also Overview Autism and vitamin D, Autoimmune , Cognitive, ADHD
Interesting Autistic studies
Autism associated with low Vitamin D
- Most Autism Risk factors are associated with low vitamin D - March 2014
- Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
- Autistics have half of the response to Vitamin D – RCT Oct 2018
- Vitamin D fights autism - trying to figure out how and why – May 2022
Autism TREATED by Vitamin D
- Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
Autism PREVENTED by vitamins before and during pregnancy
- Autism risk is reduced by Vitamin D – early pregnancy or chlldhood – Umbrella review – July 2024
- Vitamin D and autism - treat: 300 IU per kg per day, prevent: during pregnancy 5,000 IU – Feb 2017
- Autism reduced 24% for each 4 ng more Vitamin D while pregnant ( ADHD 12%) – Feb 2024
- Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
- Low Vitamin D decreases fertility and increases subsequent autism, ADHD, etc – Feb 2018
- Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
Autism and Vitamin D Receptor (not enough Vit D gets to the cells)
This list is automatically updated
- More than 30% of Autistics also have ADHD - Nov 2024
- Autism treated by an activator of the Vitamin D Receptor: supforaphane - March 2024
- Autism may be synergistically treated by Vitamin D and probiotics – July 2022
- Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Autism much more likely if poor Vitamin D Receptor – many studies
Autism - other risk factors
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
- 20 X more Parkinson's and 100X more Autism with GMO soy in China
- Note >100X increase in Autism while having GMO soy in the US
- Fewer neurons in males born from COVID-19 vaccinated mothers (rats) - Jan 2024
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- Does a vaccine increase the risk of Autism – March 2019
- Autism 2.75 X more likely in Hib vaccines containing Mercury – May 2018
- Vaccinated children had more chronic diseases - Sept 2018
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
Dr. Cannell on Autism and Vitamin D in VitaminDWiki
- Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
- Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
- Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
- Autism treated by Vitamin D: Dr. Cannell - video June 2013
- includes his list of 27 reasons to associate Vitamin D with Autism in 2013
- Many autistic children are getting some Vitamin D, Omega-3, probiotics, etc. – Aug 2019
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism treated in one person by Omega-3 plus Vitamin D – Dec 2018
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Autism risks include chemicals, deficiency of vitamin D, Omega-3 – mini-review April 2016
Pages in both categories Fertility and Autism are listed here: __
Very few other papers on the same combination
ADHD and Vitamin D Deficiency has many papers on ADHD and low Vitamin D while pregnant
Download the PDF from VitaminDWiki
The process of development depends on a number of signaling systems that regulates the progressive sequence of developmental events. Infertility and neurodevelopmental diseases, such as attention deficit hyperactivity disorder, autism spectrum disorders, and schizophrenia, are caused by specific alterations in these signaling processes. Calcium signaling plays a prominent role throughout development beginning at fertilization and continuing through early development, implantation, and organ differentiation such as heart and brain development. Vitamin D plays a major role in regulating these signaling processes that control development. There is an increase in infertility and an onset of neurodevelopmental diseases when vitamin D is deficient. The way in which vitamin D deficiency acts to alter development is a major feature of this review. One of the primary functions of vitamin D is to maintain the phenotypic stability of both the Ca2+ and redox signaling pathways that play such a key role throughout development.
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