A Scoping Review of Vitamin D for Nonskeletal Health: A Framework for Evidence-Based Clinical Practice
Clin Ther. 2023 Apr 18;S0149-2918(23)00127-3. doi: 10.1016/j.clinthera.2023.03.016 PDF is behind a paywall
Heitor O Santos 1, Carlos Eduardo E Martins 2, Scott C Forbes 3, Felipe M Delpino 4
Background: Low serum 25-hydroxy-vitamin D [25(OH)D] levels are prevalent worldwide. Although the benefits of vitamin D supplementation have focused on skeletal disorders (eg, rickets, osteomalacia, osteoporosis), emerging evidence for nonskeletal health merits further discussion.
Purpose: The purpose of this review was to critically examine the vitamin D supplementation literature pertaining to nonskeletal health to help guide clinicians.
Methods: A scoping review that included observational studies and randomized clinical trials (RCTs) was performed. Evidence from meta-analyses and individual RCTs are discussed, and controversies and future directions are considered.
Findings: 25(OH)D deficiency is a ubiquitous condition associated with multiple nonskeletal diseases, including
- cardiometabolic (heart disease, diabetes, and kidney disease),
- immune (HIV/AIDS and cancer),
- lung (from traditional chronic disorders to coronavirus disease 2019), and
- gut diseases.
Vitamin D deficiency also affects health across the life span (children, pregnant, and elderly), mental illness, and reproduction in both men and women.
In contrast, vitamin D supplementation does not necessarily improve major medical outcomes, even when low 25(OH)D levels are treated. Screening for 25(OH)D status remains an important practice, primarily for high-risk patients (eg, elderly, women with osteoporosis, people with low exposure to sunlight). It is reasonable to supplement with vitamin D to treat 25(OH)D deficiency, such that if beneficial nonskeletal health occurs, this may be considered as a coadjutant instead of the central tenet of the disease. Furthermore, optimizing dosing regimens is an important clinical consideration.
Implications: Although 25(OH)D deficiency is prevalent in nonskeletal diseases, there is no uniform evidence that vitamin D supplementation improves major medical outcomes, even when low 25(OH)D levels are corrected. Findings from RCTs warrant caution due to possible selection bias. Overall, vitamin D supplementation must be guided by circulating levels as a reasonable medical practice to correct 25(OH)D deficiency.
Some studies on restoring Vitamin D
- Restore your Vitamin D levels before surgery (Gastric Cancer in this case) - Jan 2023
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Restore in just days, not months
6 times to 55 times more likely to get the following health problems if Vitamin D deficient
- Many health problems associated with low vitamin D
click to read the studies - 55 X more likely to have bone fracture requiring surgery
- 30 X more likely for COPD becoming suddenly worse
- 25 X more likely to have senior moment
- 23 X more likely to have vertigo
- 19 X more likely to get dementia
- 17 X more likely to have muscle inflammation
- 14 X more likely to die after first cardiovascular event
- 14 X more likely for dark-skinned children to get T1 diabetes
- 12 X more likely to die from elderly pneumonia
- 11 X more likely to be allergic to peanuts
- 10 X more reactions to flu vaccine
- 10 X more likely for stroke patients to become depressed
- 9 X more likely to have Gastric Cancer
- 8 X more likely to have Autoimmune Hepatitis
- 8 X more likely for alcoholic to have Alcoholic liver disease
- 8 X more likely to get lupus
- 7 X more likely to have low birth weight infant
- 7 X more likely for pregnant teen to have anemia
- 7 X more likely to have leg pain
- 7 X increased chance of death from coronary artery disease
- 6.5 X more likely for infant to be Small for Gestational Age
- 6 X worse outcome following Sudden cardiac arrest
- 6 X more likely to get hip fracture after stroke
- 6 X more likely to die after coronary bypass
- 6 X more likely to have allergic rhinitis
- 6 X more likely to get diabetes if abdominal obese
- 6 X more likely to get cancer in children
CLICK HERE for entire 3X to 55X list for more information
Restoring vitamin D will prevent many subsequent diseases
VitaminDWik – Optimum category contains
The RDA is barely enough for the bones to survive.
Need an optimal level for the body to thrive
Example pages
- Is 50 ng of vitamin D too high, just right, or not enough
- Revisiting Vitamin D Guidelines – Holick Oct 2024 has
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015
- Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis March 2019
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- 4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
- Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
- Hypothesis by VitaminDWiki – Vitamin D levels are no longer limited by evolution
- VitaminDWiki pages with HIGH-DOSE in title 878 as of Nov 2024
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