Polymorphisms in the vitamin D receptor and risk of gout in Chinese Han male population
Rheumatology International volume 35, pages 963–971
Shi-guo Liu, Yuan-yuan Li, Rui-xia Sun, Jing-li Wang, Xin-de Li, Lin Han, Nan Chu & Chang-gui Li
Gout and Vitamin D - many studies has the following summary
Reasons to believe that Gout is associated with low vitamin D
- Acute gouty arthritis is seasonal. 1998
Increased by 32% in Spring (when vitamin D levels are the lowest) - Clinical Trials for Gout and Vitamin D
Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
Good: 50,000 IU weekly, unfortunately: D2, not D3 - Vitamin D reduces Rheumatoid arthritis
118 items - Vitamin D reduces Pain
168 items - Vitamin D reduces Inflammation category listing with
175 items - Higher incidence of gout with age (less vitamin D and gastric acid as you get older)
- Increased gout at higher Latitude (Gout and Goutiness a 1899 book
- Increased gout with soda pop
JAMA study from 2010.2 women >2 cans of soda daily 2X more likely to develop gout (Note that soda decreases vitamin D levels)- 2X more Gout if Dark Skin
WikiPedia gout is twice as likely in African American males as it is in European Americans- Gout and Calcium and vitamin D
Calcium and Vitamin D. The relationship of gout to calcium and vitamin D is complex.
Gout is associated with insulin resistance, low vitamin D levels, and inflammation, all of which interfere with muscle synthesis.
One study has found that patients with gout have lower vitamin D3 levels correlated with higher urate.- Increased gout recently (along with increased number of people being vitamin D deficient)- both blacks and whites
New Zealand 2009 publication
Gout incidence has been increasing (while vitamin D has been decreasing)- Gout has increased, but appears to be correlated with obesity/ hypertension 2011
note: both obesity and hypertension are associated with low vitamin D {FONT}
VDR
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
VitaminDWiki pages with GOUT in title
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Items found: 7Download the PDF from sci-hub via VitaminDWiki
Previous studies have showed that patients with gout showed lower serum 25(OH)D levels. As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D. In this study, we investigated whether the functional VDR polymorphisms were associated with susceptibility to gout in Chinese Han male population. A total of 504 patients with gout and 523 gout-free controls were recruited from the Affiliated Hospital of the Medical College, Qingdao University. Genotyping of VDR rs11568820, rs2228570 and rs1544410 was performed by TaqMan allele discrimination assays. An association analysis was carried out using the χ 2 test. A genotype–phenotype analysis was also conducted. Our results showed that polymorphisms of rs11568820 and rs1544410 in VDR were associated with gout in Chinese Han male population. The A allele of both rs11568820 and rs1544410 was associated with the risk of gout [P = 0.012 OR 1.251, 95 % CI (1.051–1.490); P = 0.006, OR 1.574, 95 % CI (1.139–2.175)]. However, there was no statistic significance between rs2228570 and gout (P = 0.186). Our study suggested that the polymorphisms of VDR may be relevant host susceptibility factors for the development of gout in Chinese Han male population. However, further study should be done in a larger size sample and other ethic to test and verify our result.
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