Impact of seasons on stroke-related depression, mediated by vitamin D status
BMC Psychiatry201818:359, https://doi.org/10.1186/s12888-018-1944-z
- Depression in seniors treated by weekly 50,000 IU of vitamin D – RCT Sept 2018
- Following strokes, brain scans (MRI) 3X worse in those having low vitamin D – July 2018
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Overview Stroke and vitamin D
Wonder if Omega-3 or Magnesium would help with stroke-depression?
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Depression – is it reduced by Vitamin D and or Omega-3 – RCT 2019
- How Omega-3 Fights Depression – LEF July 2016
- Ischaemic Stroke has less impact in animals supplemented with Omega-3 – Jan 2018
- Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017
- Depression greatly reduced by taking 250 mg of Magnesium Chloride daily for 6 weeks– RCT June 2017
Items in both categories Stroke and Depression are listed here:
- Nerve cells and Vitamin D – many studies
- Water-soluble form of vitamins are needed for some health problems
- Post-stroke depression not reduced by 2,000 IU of vitamin D (not a surprise) – Nov 2021
- Depression is associated with stroke if low vitamin D or winter – Nov 2018
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- No longer depressed, but risk of stroke is still 1.7X higher (did not consider low vitamin D) – May 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Post stroke depression 9X more likely if low vitamin D – Dec 2014
- Stroke patients with low vitamin D were 10X more likely to become depressed – Aug 2014
Download the PDF from VitaminDWiki
% of post-stroke depression
| Summertime | Wintertime |
| 24% | 83% |
Most stroke-depression is <40 ng
Background
This study aimed to describe the seasonal variation of depression prevalence among stroke patients at 1 month and to explore whether vitamin D plays a role in the association between seasons and post-stroke depression (PSD).
Methods
Data were collected from 402 acute stroke patients. Seasons were stratified by summertime (June to November) and wintertime (December to May) based on vitamin D status. The impact of seasons on PSD was assessed via binary logistic regression, with summertime considered the referent category. The mediating effect was used to evaluate whether vitamin D plays a role in the association between seasons and PSD.
Results
The prevalence of PSD was significantly higher in the wintertime group than in the summertime group (P = 0.003). The serum vitamin D level was lower in wintertime than in summertime (P < 0.001). Lower vitamin D levels were associated with higher HAMD scores (P < 0.001). In the multivariate analysis, patients in the wintertime group had a higher prevalence of PSD compared with those in the summertime group across all binary logistic regression models after adjusting for potential confounders. When serum vitamin D was added to the above model, there was no association between seasons and PSD (P = 0.056). Vitamin D was independently associated with PSD (OR 0.95, 95% CI 0.935–0.966, P < 0.001).
Conclusion
There was a clear seasonal variation in depression prevalence among stroke patients. Vitamin D status plays a critical mediating role in the relationship between season and post-stroke depression.