Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023

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The Four Horsemen of the Apocalypse: Cancer, Depression, Vitamin D Deficiency, and Obesity: An Observational Study

Disease Markers Volume 2023 | Article ID 9652491 | https://doi.org/10.1155/2023/9652491
Savas Tuna 1, Mehmet Akif Aydin 2, Muhammet Fatih Aydin 3

Note: They did not measure Omega-3
Serum Magnesium is a poor indicator of free Magnesium

Objective: Studies aiming at illuminating the complex relationships between cancer, obesity, 25-hydroxy vitamin D (25-OHD) deficiency, and body fat percentage are ongoing. The objective of this study was to investigate the relationships between 25-OHD deficiency, visceral fat tissue, and the Beck Depression Inventory (BDI) in cancer patients.

Methods: This study was conducted from 2013 to 2022. Patients' demographic data, such as age, sex, and body mass index (BMI), and laboratory parameters, including prealbumin, albumin, calcium, phosphorus, parathyroid hormone, 25-OHD, magnesium, hemoglobin, fat percentage, and C-reactive protein, were recorded. The Beck Depression Inventory was used to determine depression levels.

Results: A total of 223 colon cancer patients aged 19-84 undergoing chemotherapy at our clinic were included in this prospective study. The male patients' mean BMI was 22.91 ± 3.74 kg/m2, whereas that of the female patients was 26.17 ± 3.75 kg/m2. The difference was statistically significant (p < 0.001). The mean total Beck Depression Inventory score was 13 ± 9. In this patient population, 105 (47.09%) patients had minimal depression, 69 (30.94%) had mild depression, 35 (15.70%) had moderate depression, and 14 (6.28%) had severe depression. The Beck Depression Inventory score was negatively and strongly associated with BMI and moderately and negatively associated with albumin levels.

Conclusion: This study reveals a significant correlation between 25-OHD levels and the Beck Depression Inventory scores among cancer patients. We believe that 25-OHD levels may be used to determine the presence of depressive symptoms in cancer patients. However, further comprehensive multicentre studies are needed to draw more definitive conclusions.
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Intervention of Vitamin D for Depression

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Meta-analyses of Vitamin D and Depression

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VitaminDWiki – Depression summary contains

• Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
• Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
• Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses – Jan 2023
• Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023
• Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
• Depression treated by Omega-3 (again) – meta-analysis Aug 2019
• Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
• Omega-3, Magnesium, and St. Johns' Wort also decrease depression
  • Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
  • Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
• Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
• There are 268 items in the Depression category in VitaminDWiki

Some recent publications

• Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis June 2023
• Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
• Post-partum depression and low Vitamin D - many studies
• Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023

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VitaminDWiki - 14 studies in both categories Depression and Magnesium

This list is automatically updated