Serum Vitamin D Levels in Patients with Keratoconus.
Ocul Immunol Inflamm. 2019 Apr 22:1-6. doi: 10.1080/09273948.2019.1604002.
Akkaya S 1, Ulusoy DM 1.
1 .Department of Ophthalmology , Kayseri Training and Research Hospital , Kayseri , Turkey.
Notes
- This is one of many vision problems associated with Low Vitamin D
- This is a rare disease (200,000 people in the US)
- Unknown cause
- The concentration of vitamin D in tears is 25% higher than that in the blood
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- Vitamin D treats and prevents a variety of eye problems (need 70 ng) – June 2018
- All people with Cataracts had low vitamin D levels – April 2019
- Vitamin D is the best vitamin to fight glaucoma – May 2018
- The drier the eye, the lower the Vitamin D – May 2017
Vision category starts with the following
- 12% larger pupils in children who are Vitamin D deficient – Feb 2024 parasympathetic nervous system?
- Myopia, AMD, Dry Eye, and Diabetic Retinopathy are all associated with low Vitamin D - April 2023
- An ocular disease can be associated with low vitamin D and 1 of 5 poor vitamin D genes – June 2022
- Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
- Vitamin D treats and prevents a variety of eye problems (need 70 ng) – June 2018
- Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015
- Tears often have 25 % higher levels of vitamin D than does blood
Vision problems having many studies on VitaminDWiki
- Uveitis (inflamed eye) and Vitamin D - many studies
- Age-Related Macular Degeneration and Vitamin D - many studies
- Cataracts and Vitamin D - many studies
- Diabetic Retinopathy associated with low Vitamin D - many studies
- 7+ studies of Glaucoma and Vitamin D
- Dry Eyes treated by Omega-3 and Vitamin D – many studies
- 21+ studies of Myopia and Vitamin D
PURPOSE:
To evaluate serum 25-hydroxyvitamin D levels in patients with keratoconus (KC) and its association with disease severity and to compare vitamin D levels with those of age- and sex-matched healthy individuals.
METHODS:
This study included 100 patients with KC and 100 non-atopic healthy controls. Serum vitamin D levels were measured using liquid chromatography-tandem mass spectrometry and compared between the study groups. KC severity was graded as mild (K = 43.1-46.9 D), moderate (K = 47-50 D), and severe (K > 50 D). Vitamin D levels were classified as deficient (≤10 ng/mL), insufficient (11-20 ng/mL), and optimal (>20 ng/mL).
RESULTS:
The mean serum vitamin D level was significantly lower in the KC group than in the control group (12.18 ± 5.05 ng/mL vs 15.18 ± 5.81 ng/mL; p < .001). Vitamin D deficiency (≤10 ng/mL) was observed in 54.0% of the KC patients and 34.0% of the controls (p = .011). Multivariable logistic regression analysis revealed that having deficient vitamin D level increased the presence of KC 2.9 fold (p = .021, 95% confidence interval, 1.17-6.95). Decreasing serum vitamin D levels were not significantly associated with increasing severity of KC (p = .311). Although the rate of patients with deficient vitamin D was the highest in the severe KC group, distribution of vitamin D levels were not significantly different among KC groups (p = .326).
CONCLUSION:
The patients with KC had lower serum vitamin D levels than those of age- and sex-matched healthy controls. The present study could be a valuable entry point for further researches investigating the potential link between vitamin D and KC.
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