4,000 IU of Vitamin D - many pages

111+ VitaminDWiki pages with 4,000 or 4000 in the title
4000 IU daily - rare risk of hypercalcemia - meta-analysis Feb 2023 (can reduce risk by subtracting Calcium or adding Vitamin K2)
VitaminDWiki – Consensus Vitamin D category contains:
Charts from Overview Vitamin D Dose-Response 4,000 IU ==> 50-55 ng
See also VitaminDWiki

111+ VitaminDWiki pages with 4,000 or 4000 in the title

This list is automatically updated

Items found: 111

Title		Modified
Total Testosterone increased if take more than 4,000 IU vitamin D daily – meta-analysis Sept 2024		26 Sep, 2024
Prostate cancer risk reduced by Vitamin D (4000 IU daily) – June 2024		07 Aug, 2024
Vitamin d levels were restored from hemodialysis by 70,000 IU weekly total in 4 weeks - Feb 2024		25 Feb, 2024
4,000 IU of Vitamin D - many pages		19 Dec, 2023
4,000 IU of daily Vitamin D during pregnancy is good (Mongolia this time) – RCT Oct 2023		24 Oct, 2023
Just 4,000 IU of vitamin D was not enough to halt senior falls – July 2023		19 Jul, 2023
Respiratory infections reduced by 63 percent with 4000 IU vitamin D daily - RCT Dec 2012		17 Jul, 2023
Childhood and youth obesity – more than 4,000 IU vitamin D average daily would help – meta-analysis Jan 2023		12 Jan, 2023
Vitamin D daily - Evolution: 4,000 IU, Government: 800 IU– Veith Oct 2022		28 Oct, 2022
Yet another Vitamin D call-to-action (4000 IU) - Feb 2022		04 Oct, 2022
4X less likely to get COVID following 4,000 IU daily for a month – RCT April 2022		12 Jun, 2022
Risk of Frailty reduced 4X by 4,000 IU of vitamin D – RCT April 2022		10 Apr, 2022
Call for immediate action - Fight COVID-19 with vitamin D (up to 4,000 IU) - Jan 28, 2021		27 Feb, 2022
4,000 IU of Vitamin D is too small a dose to help Obese - RCT Feb 2022		09 Feb, 2022
Chronic Heart Failure reduced by 4,000 IU daily for a year – RCT April 2016		07 Oct, 2021
Minimum National Vitamin D recommendations range from 200 to 4,000 IU – July 2021		15 Jul, 2021
Vitamin D can improve bone health – 47 guidelines (range of 200 to 4000 IU daily) – May 2021		08 May, 2021
Consensus: Upper Limit of daily Vitamin D intake is still 4,000 IU (if you do not reduce Calcium) – Aug 2020		18 Dec, 2020
Evidence of Vitamin D fighting COVID-19 etc. - take 4,000 IU if less than 20 ng (UK) – Dec 1, 2020		06 Dec, 2020
4,000 IU of vitamin D for 1 month does not help (muscles in this case) – RCT Jan 2020		21 Sep, 2020
MRSA Carriers not helped by 4,000 IU of Vitamin D (probably poor Vitamin D Receptor) – RCT Sept 2018		14 Jul, 2019
Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019		10 Jul, 2019
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019		04 Jun, 2019
4,000 IU of Vitamin D is OK - 19 organizations agree - 2018		19 May, 2019
Advanced Colorectal Cancer survival is increased somewhat with 4,000 IU of vitamin D – RCT April 2019		10 Apr, 2019
Periodontitis treated by 4,000 IU of Vitamin D (pilot study) - March 2019		27 Mar, 2019
Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018		20 Feb, 2019
4,000 IU Vitamin D daily during pregnancy (Mongolia) was good – RCT Dec 2018		14 Dec, 2018
Sweden had banned selling more than 4,000 IU of vitamin D, Supreme Court canceled it – Dec 2018		03 Dec, 2018
1200 mg is too much Calcium for seniors if take 4,000 IU of vitamin D – Oct RCT 2018		16 Oct, 2018
Vitamin D during lactation – range from 4,000 IU daily to 150,000 IU monthly – Sept 2018		25 Sep, 2018
Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018		06 Sep, 2018
One-A-Day capsule with 4,000 IU of Vitamin D		14 Aug, 2018
Dementia – clinical trial using 4,000 IU of Vitamin D– 2023		02 Aug, 2018
Vitamin D - at least 4,000 IU to achieve 40-60 ng and reduce risk of early death – Holick June 2018		04 Jun, 2018
No genetic response to 4,000 IU of Vitamin D (other studies disagree) – RCT April 2018		15 Apr, 2018
Nordic Walking and 4,000 IU of vitamin D lowered cholesterol, fat, weight, and lipids (senior women) – RCT Feb 2018		09 Mar, 2018
Bone loss during black pregnancies – 4000 IU of vitamin D was not enough – Dec 2017		12 Dec, 2017
Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021		28 Nov, 2017
Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis Sept 2017		02 Oct, 2017
Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017		05 Sep, 2017
Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP – Aug 2017		01 Sep, 2017
Obese helped with resistance training by 4000 IU of vitamin D – RCT Aug 2012		23 Aug, 2017
Beef was more tender and contained more vitamin D when finishing diet included 4,000 IU of Vitamin D – Dec 2017		03 Aug, 2017
4,000 IU of Vitamin D daily is safe, but takes a year to plateau (Best-D) – RCT Dec 2016		23 Jul, 2017
1,000 IU of Vitamin D while pregnant helped a little bit (4,000 IU helps a lot) – RCT Dec 2016		20 Jul, 2017
RTI – Feel much better if increase vitamin D level above 40 ng (4000 IU) – RCT Sept 2015		18 Jul, 2017
3 to 6 months to plateau with 4,000 IU vitamin D daily (Cardiac Patients) – June 2017		12 Jun, 2017
Pregnancy complications reduced with 4000 IU of vitamin D - 2RCT Jan 2013		21 Mar, 2017
Nasal polyposis greatly decreased by 4,000 IU of vitamin D for 4 weeks - 2014		12 Mar, 2017
Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT Sept 2015		13 Jan, 2017
Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016		02 Dec, 2016
Leg bone (tibia) grew thicker with 4,000 IU of vitamin D and Calcium – RCT Aug 2016		19 Aug, 2016
4000 IU Vitamin D Safe and Effective For Healthy Pregnant Women – June 2011		23 May, 2016
Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015		16 Apr, 2016
Athletic performance and recovery benefits of Vitamin D (4000-5000 IU and Vitamin K) – Aug 2015		01 Mar, 2016
Asthma trial underway - 4,000 IU during pregnancy - March 2014		27 Jan, 2016
Battling the winter blues with vitamin D (4000 IU) Dec 2015		22 Dec, 2015
Low risk Prostate Cancer decreased with 4,000 IU of vitamin D – July 2012		21 Dec, 2015
4000 IU Vitamin D Safe and Effective For Healthy Pregnant Women – RCT June 2011		18 Dec, 2015
Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015		05 Nov, 2015
Optimal Vitamin D during pregnancy - 4000 IU March 2012		29 Sep, 2015
Hypertension reduction sometimes needs more than 4,000 IU of vitamin D for 6 months – RCT Oct 2014		22 Sep, 2015
4000 IU increased peak power in exercise vs placebo April 2010		27 Jul, 2015
Vitamin D measured in 4000 people for many years – longitudinal associations – May 2015		31 May, 2015
4,000 IU raised vitamin D levels during pregnancy – July 2014		06 May, 2015
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015		02 Apr, 2015
Seniors need at least 4,000 IU vitamin D, no test needed – Consensus Jan 2014		31 Mar, 2015
Need 4,000 IU vitamin D to prevent falls, no vitamin D test needed – Consensus Jan 2014		31 Mar, 2015
4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT Jan 2013		16 Mar, 2015
Women taking 4,000 IU reduced pregnancy risks in half RCT May 2010		16 Mar, 2015
Adding 4,000 IU of vitamin D daily at 20 weeks pregnancy not help much – RCT March 2014		18 Feb, 2015
Is 4000 IU the best Vitamin D dose for seniors – RCT underway – Feb 2015		08 Feb, 2015
Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT Oct 2013		27 Jan, 2015
Newborn Apgar score slightly higher if deficient mother had daily 4,000 IU vitamin D – RCT March 2014		06 Jan, 2015
Cancer – will 4,000 IU of vitamin D daily help in one month (no) – VIDAFACT Dec 2014		31 Dec, 2014
Best Vitamin D- 40 to 52 ng, achieved with 4000 – 6000 IU daily – Heaney Oct 2014		10 Nov, 2014
Infectious Disease typically not treated if use less than 4000 IU vitamin D daily– review Oct 2014		31 Oct, 2014
4000 IU RCT reduces type 2 diabetes HOMA by 24% and CRP by 64% April 2010		28 Oct, 2014
Diabetes prevention RCT kicked off: adding 4,000 IU vitamin D - Oct 2013		10 Sep, 2014
PSA levels in blacks were not changed by 3 months of 4,000 IU of vitamin D (not enough) – June 2014		02 Aug, 2014
Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014		25 Jul, 2014
Forum discussions on Vitamin D - Treato 15,000 positive, 4,000 negative - July 2014		02 Jul, 2014
Little change in Calcium absorption when taking 400 vs 4,000 IU of vitamin D – Oct 2012		27 May, 2014
More Calcium absorbed with more vitamin D – 6.7% more with 4000 IU – RCT March 2014		27 May, 2014
Defining normal level of vitamin D (need 4000-5000 IU) - Heaney Spring 2013		26 May, 2014
Female healthcare employees: 4 percent took more than 4,000 IU vitamin D daily – May 2014		13 May, 2014
European adults can take 4000 IU of vitamin D – July 2012		13 May, 2014
4000 IU vitamin D daily reduced inflammation after heart attack – Review and RCT Jan 2013		05 Apr, 2014
Many healthy African Americans got above 33 ng with 4,000 IU of vitamin D – RCT March 2014		25 Dec, 2013
Inflammation in African Americans not reduced with 3 months of 4000 IU of vitamin D – RCT Dec 2013		25 Dec, 2013
Extra 4,000 IU daily raised the vitamin D levels of blacks to that of whites – July 2012		25 Dec, 2013
Calcium and 4,000 IU Vitamin D in Postmenopausal Women – RCT Nov 2013		06 Nov, 2013
Collegiate Swimmers getting 4000 IU of vitamin D had fewer injuries – March 2013		03 Nov, 2013
Pregnant women should have 4,000 IU of vitamin D – Topic review June 2013		04 Sep, 2013
Pregnancy needs 4000 IU of vitamin D: current opinion - June 2013		24 Jun, 2013
Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013		20 Mar, 2013
Insulin improvement in obese teens with 4000 IU of vitamin D – RCT Feb 2013		11 Mar, 2013
Obese teens needed 4000 IU of vitamin D - Nov 2011		07 Nov, 2012
Fewer falls and fractures as vitamin D is increased – 1800 to 4000 IU July 2010		24 Jun, 2012
40 ng response plateau to 2000 to 4,000 IU of vitamin D – June 2012		19 Jun, 2012
Perhaps Stress fractures 2X less frequent if 4000 IU of vitamin D – June 2011		12 Jun, 2012
4000 IU vitamin D not enough to treat diabetes in overweight blacks in 3 months – May 2012		02 May, 2012
4000 IU vitamin D was not enough to reduce obesity – PhD 2010		21 Jul, 2011
Recommend 2500-4000 IU per day to reduce all-cause mortality by 18%– Grant Netherlands April 2010		13 Jul, 2011
4000 IU vitamin D and exercise for overweight – PhD 2010		02 Jul, 2011
4000 IU vitamin D improved glycemic control for type 1 diabetes – Nov 2010		11 Nov, 2010
4000 IU Vitamin D intervention helped elderly bones – March 2010		16 Oct, 2010
2500 to 4000 IU vitamin D would decrease specific disease rates- April 2010		31 Aug, 2010
4000 IU vitamin D3 improves insulin resistance – Feb 2010		01 Aug, 2010
Migraine headaches associated with low vitamin D, 4,000 IU often helps – review Aug 2019		No value for 'modification_date_major'

4000 IU daily - rare risk of hypercalcemia - meta-analysis Feb 2023 (can reduce risk by subtracting Calcium or adding Vitamin K2)

Long-term supplementation with 3200 to 4000 IU of vitamin D daily and adverse events: a systematic review and meta-analysis of randomized controlled trials
European Journal of Nutrition February 2023
Armin Zittermann, Christian Trummer, Verena Theiler-Schwetz & Stefan Pilz

Note: No indication of how much Calcium (food or supplement) each group was taking
Nor if any vitamin K2 was taken (which reduces Calcium in the blood)

Purpose
The upper tolerable intake level for vitamin D in the general population has been set at 4000 international units (IU) daily, but considerable uncertainty remains. We summarized the reported harmful effects of a daily vitamin D supplement of 3200–4000 IU in trials lasting ≥ 6 months.

Methods
We performed a systematic review and meta-analysis of randomized controlled trials in several databases and identified 22 trials reporting safety data. Parameters of calcium metabolism, falls, hospitalization, and mortality were assessed.

Results
The selected trials comprised a total number of 12,952 participants. All trials used supplemental vitamin D3. The relative risk (RR) of hypercalcemia in the vitamin D vs. control arm was 2.21 (95%CI: 1.26–3.87; 10 studies), with a vitamin D-induced frequency of hypercalcemia of 4 cases per 1000 individuals. Subgroup analysis in trials with > 100 and ≤ 100 study participants revealed an RR of 2.63 (95%CI: 1.30–5.30; 7 studies) and 0.80 (95%CI: 0.24–2.62; 3 studies), respectively (Pinteraction = 0.06). Risks of falls and hospitalization were also significantly increased in the vitamin D arm with an RR of 1.25 (95%CI: 1.01–1.55; 4 studies) and 1.16 (95%CI: 1.01–1.33; 7 studies), respectively. Risks of hypercalciuria, kidney stones, and mortality did not differ significantly between study arms. The quality assessment revealed a high risk of incomplete reporting of safety-related outcome data.

Conclusion
Supplemental vitamin D doses of 3200–4000 IU/d appear to increase the risk of hypercalcemia and some other adverse events in a small proportion of individuals, indicating that this dose is not completely safe. In future studies, rigorous reporting of safety-related outcomes is needed when using moderately high doses of vitamin D.
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