The earlier the better: preconception vitamin D and protection against pregnancy loss.
Lancet Diabetes Endocrinol. 2018 Jun 5. pii: S2213-8587(18)30178-5. doi: 10.1016/S2213-8587(18)30178-5. [Epub ahead of print]
Hewison M, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, Centre for Endocrinology, Diabetes and Metabolism, U. of Birmingham and Birmingham Health Partners, Birmingham, B15 2TT, UK m.hewison at bham.ac.uk.
PDF is available free at Sci-Hub
PMID: 29884467 DOI: 10.1016/S2213-8587(18)30178-5
This is an editorial comments on
Mumford SL, Garbose RA, Kim K, et al.
Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol 2018; online May 30. In VitaminDWiki Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
Preconception supplementation appears to reduce problems with
Becoming pregnant
Miscarriage
First trimester supplementation reduces problems with
Infant teeth
Autism
Asthma
Healthy pregnancies need lots of vitamin D has the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for details
Problem | Vit. D Reduces | Evidence |
| 0. Chance of not conceiving | 3.4 times | Observe |
| 1. Miscarriage | 2.5 times | Observe |
| 2. Pre-eclampsia | 3.6 times | RCT |
| 3. Gestational Diabetes | 3 times | RCT |
| 4. Good 2nd trimester sleep quality | 3.5 times | Observe |
| 5. Premature birth | 2 times | RCT |
| 6. C-section - unplanned | 1.6 times | Observe |
| Stillbirth - OMEGA-3 | 4 times | RCT - Omega-3 |
| 7. Depression AFTER pregnancy | 1.4 times | RCT |
| 8. Small for Gestational Age | 1.6 times | meta-analysis |
| 9. Infant height, weight, head size within normal limits | RCT | |
| 10. Childhood Wheezing | 1.3 times | RCT |
| 11. Additional child is Autistic | 4 times | Intervention |
| 12.Young adult Multiple Sclerosis | 1.9 times | Observe |
| 13. Preeclampsia in young adult | 3.5 times | RCT |
| 14. Good motor skills @ age 3 | 1.4 times | Observe |
| 15. Childhood Mite allergy | 5 times | RCT |
| 16. Childhood Respiratory Tract visits | 2.5 times | RCT |
RCT = Randomized Controlled Trial
Fertility and Sperm category contains the following summary
See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" etc. in 18 VitaminDWiki titles
Fertility
- Having a good level of vitamin D before conception helps – Aug 2018
- Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017
- Poor fertility in both women and men associated with low vitamin D – review Feb 2018
- Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
- Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
See also
Some related publications by M Hewison
- Vitamin D, the placenta and early pregnancy: effects on trophoblast function Feb 2018 PDF online
- Dysregulation of maternal and placental vitamin D metabolism in preeclampsia Feb 2017 PDF online
- Search VitaminDWiki for HEWISON 905 items as of Aug 2018
- Decidua immunity and Vitamin D – dissertation July 2018 Hewison was thesis advisor
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