- SSRI problems - Perplexity AI June 2025
- 6+ VitaminDWiki pages have ANTIDEPRESSANT in the title
- Antidepressant use and cognitive decline in patients with dementia - Feb 2025
- SSRI Drugs Can Cause Chronic Fatigue Syndrome - Mercola April 2024
- Some SSRIs (fluoxetine) inhibit CYP27A1, thus reducing Vitamin D
- VitaminDWiki – Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
- VitaminDWiki – Depression has many antidepressant entries
- VitaminDWiki – Overview Fibromyalgia or Chronic Fatigue and vitamin D
SSRI problems - Perplexity AI June 2025
| Health Problem | Occurrence | RateSeverity/Impact |
| Overall adverse events | 75-80% | Any side effect |
| Sexual dysfunction | 25-73% | Most troublesome long-term |
| Somnolence/Drowsiness | 16-59% | Varies by specific SSRI |
| Memory impairment | 51% | Cognitive impact |
| Decreased concentration | 50% | Cognitive impact |
| Weight gain | 45-55% | Long-term users |
| Withdrawal syndrome | 42.9-56% | Upon discontinuation |
| Nausea | 11.9-25.7% | Most common early effect |
| Bleeding risk increase | 36% | Serious complication |
| Hyponatremia (elderly) | 9-39% | Serious in elderly |
| Serotonin syndrome | 0.07-0.19% | Rare but life-threatening |
The occurrence and severity of side effects can vary significantly between different SSRIs, with paroxetine generally showing the highest rates of sexual dysfunction and weight gain, while citalopram appears to be the best-tolerated overall.
6+ VitaminDWiki pages have ANTIDEPRESSANT in the title
The list is automatically updated
Antidepressant use and cognitive decline in patients with dementia - Feb 2025
Antidepressant use and cognitive decline in patients with dementia: a national cohort study
BMC Medicine volume 23, Article number: 82 (2025)
Minjia Mo, Tamar Abzhandadze, Minh Tuan Hoang, Simona Sacuiu, Pol Grau Jurado, Joana B. Pereira, Luana Naia, Julianna Kele, Silvia Maioli, Hong Xu, Maria Eriksdotter & Sara Garcia-Ptacek
Background
Dementia is associated with psychiatric symptoms but the effects of antidepressants on cognitive function in dementia are understudied. We aimed to investigate the association between antidepressants and cognitive decline in patients with dementia, and the risk of severe dementia, fractures and death, depending on antidepressant class, drug, and dose.
Methods
This is a national cohort study. Patients with dementia registered in the Swedish Registry for Cognitive/Dementia Disorders-SveDem from May 1, 2007, until October 16, 2018, with at least one follow-up after dementia diagnosis, and who were new users of antidepressants, were included. Antidepressant use as a time varying exposure defined during the 6 months leading up to dementia diagnosis or each subsequent follow-up. We used linear mixed models to examine the association between antidepressant use and cognitive trajectories assessed by Mini-Mental State Examination (MMSE) scores. We used Cox proportional hazards models to calculate the hazard ratios for severe dementia (MMSE score < 10), fracture, and death. We compared antidepressant classes and drugs, and analyzed dose–response.
Results
We included 18740 patients (10 205 women [54.5%]; mean [SD] age, 78.2 [7.4] years), of which 4271 (22.8%) received at least one prescription for an antidepressant. During follow-up, a total of 11912 prescriptions for antidepressants were issued, with selective serotonin reuptake inhibitors (SSRI) being the most common (64.8%).
Antidepressant use was associated with
- faster cognitive decline (β (95% CI) = − 0.30(− 0.39, − 0.21) points/year),
- in particular sertraline (− 0.25(− 0.43, − 0.06) points/year),
- citalopram (− 0.41(− 0.55, − 0.27) points/year),
- escitalopram (− 0.76(− 1.09, − 0.44) points/year), and
- mirtazapine (− 0.19(− 0.34, − 0.04) points/year) compared with non-use.
The association was stronger in patients with severe dementia (initial MMSE scores 0–9). Escitalopram showed a greater decline rate than sertraline. Compared with non-use, dose response of SSRIs on greater cognitive decline and higher risks of severe dementia, all-cause mortality, and fracture were observed.
Conclusions
In this cohort study, current antidepressant use was associated with faster cognitive decline; furthermore, higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality. These findings highlight the significance of careful and regular monitoring to assess the risks and benefits of different antidepressants use in patients with dementia.
Download the PDF from VitaminDWiki
>100 SSRI problems (including the Feb 2025 study) GreenMedInfo June 2025
SSRI Drugs Can Cause Chronic Fatigue Syndrome - Mercola April 2024
STORY AT-A-GLANCE
- SSRIs, which increase serotonin levels, have been linked to chronic fatigue syndrome (CFS). A study showed that administering Prozac (fluoxetine) to mice at high dosages induced symptoms of CFS, suggesting a link between excessive serotonin levels and the condition
- Symptom reversal was achieved with the serotonin inhibitor fenclonine
- Other serotonin inhibitors include Benadryl, the H2 blocker Pepcid (famotidine), aspirin, progesterone and GABA
- Branched-chain amino acids, tyrosine, phenylalanine and L-theanine can also help reduce serotonin levels
- GABA is a more effective solution for conditions typically treated with SSRIs, such as depression and anxiety, without the adverse effects associated with elevated serotonin
- Reducing intake of linoleic acid (LA), found in high amounts in seed oils and certain meats, is recommended if you have CFS, as excess LA impair your mitochondrial function and cellular energy production
- Note: LAs reduces the Omage-3
Download the PDF from VitaminDWiki
Some SSRIs (fluoxetine) inhibit CYP27A1, thus reducing Vitamin D
Perplexity AI April 2024
The specific SSRIs that have been noted to inhibit CYP27A1 include citalopram, fluoxetine, and sertraline17. This inhibition can lead to drug-drug interactions, particularly in patients who are on multiple medications, as CYP27A1 plays a role in the metabolism of various substances1417.
VitaminDWiki - Genetics chart shows the vitamin D genes
VitaminDWiki – Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
VitaminDWiki – Depression has many antidepressant entries
2X increase in risk if Sudden Cardiac Death if take antidepressent drugs for > 6 years - April 2025
The Hidden Dangers of Antidepressants and Why It's So Hard to Stop Taking Them - Feb 2025
Just How Far Will the FDA Go To Protect A Bad Drug? (SSRI ) - Dec 2023
37% of Americans take drugs that list depression as a possible side effect - July 2023
A decade of use of antidepressive drugs doubles CVD - Oct 2022
SSRIs cause long term sexual dysfunction (prescription warnings in Europe and Canada)
Why Are Antidepressants (SSRIs) so Harmful? - Nov 2023
Antidepressant drugs often not effective and hard to stop using - Oct 2022
VitaminDWiki – Overview Fibromyalgia or Chronic Fatigue and vitamin D