Omega-3 for just 3 months greatly reduced psychosis for 80 months – RCT Aug 2015

Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study

Nature Communications 6, Article number: 7934 doi:10.1038/ncomms8934
G. Paul Amminger, Miriam R. Schäfer, Monika Schlögelhofer, Claudia M. Klier & Patrick D. McGorry

Survival without psychotic event (clipped from PDF)

Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue, omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia.

We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo.

We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years. Here we show that brief intervention with omega-3 PUFAs reduced both the risk of progression to psychotic disorder and psychiatric morbidity in general in this study. The majority of the individuals from the omega-3 group did not show severe functional impairment and no longer experienced attenuated psychotic symptoms at follow-up.

 Download the PDF from VitaminDWiki

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Daily: 700 mg of EPA + 480 mg of DHA: standard dosing of Omega-3

Suggestion by Henry Lahore of VitaminDWiki

This is the most amazing study I can recall seeing. 3 months supplementation ==> 80 months of prevention
It appears that young adults at high risk of psychosis should take Omega-3 for a while and perhaps vitamin D as well
Extremely low cost and low risk of taking these supplements.

See also VitaminDWiki

• Omega-3 prevents PTSD and some mood disorders - Aug 2015
• Omega-3, Vitamin D, and other nutrients decrease mental health problems – March 2015
• Depression category listing has 268 items along with related searches
• Omega-3 and Vitamin D each treat many mental health problems - April 2018
• Supplements survey: Fish oil 1st, Vitamin D 4th, Magnesium 6th, Calcium 7th - March 2015
• Overview: Omega-3 many benefits include helping vitamin D
• I use Vectomega brand of Omega-3 – Admin of VitaminDWiki, May 2014
• Low Vitamin D Permeates All Stages of Psychosis – April 2015
• First episode psychosis associated with a 33 percent lower vitamin D in 3 races – Sept 2013
• Psychiatric disorders 4X more likely in teens if low vitamin D - Nov 2011
• Vitamin D, Omega-3 supplementation helps cognition – perhaps due to serotonin – Feb 2015
• Psychosis risk reduced for 80 weeks by just 12 weeks of Omega-3 – RCT Aug 2017
• PSYCHOSIS 417 items as of May 2018

Pages listed in BOTH the categories Omega-3 and Depression

See also web

• Fish oil helps minimize disorders for those at risk of schizophrenia, study finds LA Times review of the study on this page
• Omega-3 fatty acids in first-episode schizophrenia - a randomized controlled study of efficacy and relapse prevention (OFFER): rationale, design, and methods.
  May 2015, same 12 week study? free PDF on-line
• Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids Jan 2015 - same study?, free PDF online
• Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. Feb 2014 free PDF online