Early lifecycle UV-exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes.
Am J Hum Biol. 2019 Jun 11:e23272. doi: 10.1002/ajhb.23272.
Lucock M1, Thota R2, Garg M2, Martin C1, Jones P1, Furst J3, Yates Z4, Jablonski NG5, Chaplin G5, Veysey M6, Beckett E1,7.
No Osteo if more UV in first trimester?
total solar irradiance in 90 days post conception
Taller if more UV in first trimester
Most likely same benefits from More Sun, More UV (lamps), or More Vitamin D
- Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018
- Childhood Asthma risk greatly reduced if mothers were given 4,400 IU Vitamin D daily – RCT 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Vitamin D congress on pregnancy and childhood diseases – April 2019
- Pregnancies need a lot of vitamin D, even before conception - Hollis Dec 2018
- First trimester Vitamin D deficiency in associated with placental inflammation, etc. – July 2018
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:Dark Skin
30 ; Depression 21 ; Diabetes 44 ; Obesity 17 ; Hypertension 44 ; Breathing 36 ; Omega-3 44 ; Vitamin D Receptor 24 Click here for details - All items in category Infant/Child
854 items - Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
- 38+ papers with Breastfed etc, in the title
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- 53+ preeclampsia studies
- 94+ studies with PRETERM in the title
- Fertility problem (PCOS) reduced by vitamin D, etc: many studies 15+
- 94+ Gestational Diabetes
- Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
- Post-partum depression and low Vitamin D - many studies 15+ studies
- Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 5+ studies
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142 items along with related searches - (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for detailsProblemVit. D
ReducesEvidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
Items in both categories Pregnancy and UV are listed here:
- Air pollution decreases Vitamin D levels (while pregnant in this case) – July 2022
- More UV during first trimester, less Osteoporosis in offspring – June 2019
- Low Vitamin D if low UV (Pregnant Japanese, 2012) – March 2019
- Ultraviolet light (like Vitamin D) is great, especially while pregnant – Aug 2018
- Extreme preterm survival 30 percent less likely if little sunshine 23-28 weeks – June 2015
- Grassroots PDF and video updates May and June 2010
UV and D starts with
381 items in UV category see also - Overview UV and vitamin D
- Vitamin D bulb for use in the home - or perhaps office,
- Sun and UV
- Sun and Vitamin D category has
331 items - UV and Vitamin D calculators, Vitamin D from low-cost UVB lamps
- UVB added in classroom reduced cavities, increased height, increased academics. etc
- How to safely get Vitamin D at home from a UV lamp or LED
- Vitamin D production after UVB exposure – A comparison of exposed skin regions – Feb 2015
- Ultra-low UV LED added to office desk lamp would add 7 ng to winter Vitamin D levels – RCT Oct 2022
- Seniors get about 4X less vitamin D from the sun or UVB
- Vitamin D from the sun without the heat (silver-coated plexiglass)
- COVID and other Virus fought by UV - many studies 16+
- 3.3 X more likely to be Vitamin D deficient if wear long-sleeves – Oct 2022
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies UV, etc.
Download the PDF from Sci-Hub via VitaminDWiki
OBJECTIVES:
Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long-term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV-exposure on late-life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively).METHODS:
Six hundred and forty nine subjects were examined for vitamin D2 and D3 (HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire.RESULTS:
Solar irradiance over the first 90 days postconception correlated positively with late-life vitamin D3 (R2 = .0140; P = .0082; β = .1075), but not vitamin D2 levels. It also correlated positively with female adult height (R2 = .170; P = .0103; β = .1291) and negatively with the occurrence of female osteoporosis (P = .0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P = .0009).CONCLUSIONS:
Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.More UV during first trimester, less Osteoporosis in offspring – June 2019Printer Friendly Follow this page for updates5982 visitors, last modified 12 May, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 12169 Taller is more UV.jpg admin 20 Jun, 2019 17.82 Kb 484 12168 First Timester UV Osteo.jpg admin 20 Jun, 2019 17.11 Kb 506 12167 First Timester UV Sci-Hub.pdf admin 20 Jun, 2019 1.01 Mb 576
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