Cancer and Vitamin D - many studies

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87 Meta-analyses in VitaminDWiki with CANCER etc in the title

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33 Intervention trials in VitaminDWiki with CANCER etc in title

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18 Omega-3 VitaminDWiki studies with CANCER etc in title (Oct 2022)

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VitaminDWiki – Cancer category contains

• Cancer 304 items Overview Cancer and vitamin D
• Cancer and Vitamin D - many studies
• After Cancer Diagnosis 117 items
• Bladder Cancer 28 items
• Breast Cancer 263 items Overview Breast Cancer and Vitamin D
• Colon Cancer 147 items Overview Cancer-Colon and vitamin D
• Leukemia 19 items
• Liver Cancer 17 items
• Lung Cancer 56 items Overview Lung cancer and vitamin D
• Lymphoma Cancer 26 items
• Other Cancer 69 items
• Ovarian Cancer 26 items
• Pancreatic Cancer 59 items
• Prostate Cancer 107 items Overview Prostate Cancer and Vitamin D
• Skin Cancer 122 items Overview Suntan, melanoma and vitamin D
• Childhood Cancers - Vitamin D can help - many studies
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• 13 Cancers are helped by Vitamin D – Biobank July 2023
• 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
• Vitamin D prevents and treats cancer in many ways – May 2021
• Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
• Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
• 8 ways that Cancer might be prevented by Vitamin D - June 2019
• Cancer stem cells and Vitamin D - many studies
• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
• Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Melanoma 25 X more likely if low vitamin D – Feb 2018
• Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018

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VitaminDWiki – Cancer increases if poor Vitamin D Receptor

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Vitamin D Receptor (Cancers OR Viruses) - many studies
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 23 articles
• Breast Cancer and VDR 24 articles
• Colon Cancer and VDR 14 articles
• Prostate Cancer and VDR 7 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves
    by actively reducing Receptor activation

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39+ VitaminDWiki Mortality pages have CANCER in the title

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20 Most-visited pages in Cancer (general) category

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89+ Cancer Meta-analyses in VitaminDWiki

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See also web

• Phrases associated with cancer NYT Jan 2015
  “failed tamoxifen”,“platinum resistant” or “refractory” patient, “relapsed” scans which are “clean,” “positive” or “advancing” spells trouble
  nodes have been “harvested”; a tumor is “indolent, “minimal or acceptable side effects,” scanxiety,
  Nothing about vitamin D
• How cancer cells form tumors by reaching out with ‘cables’ and grabbing cells Jan 2016 (nothing about vitamin D)
  "Surprisingly, as little as five percent of cancerous cells are needed to form the tumors, a ratio previously unknown."
  “It’s that these cells go out and actively recruit. It’s complicated stuff, and it’s not passive. No one had a clue that there were specialized cells in this process, and that it’s a small number that pulls all the rest in.”
  Images from the movie

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VitaminDWiki – Cancer - After diagnosis category contains

• Most cancers reduce vitamin D levels
• Most cancer treatments (chemo, radiation) further lower Vitamin D
• Higher levels of vitamin D minimize many side-effects of cancer therapy
• High levels of vitamin D augment many chemotherapies
• High levels of vitamin D augment cancer immunotherapies
• High levels of vitamin D can kill some cancer cells 1,720 items 12/2023
• Some cancers deactivate the vitamin D receptor

Example VitaminDWiki Studies

• Cancer and Vitamin D - many studies
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022
• Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
• Vitamin D prevents and treats cancer in many ways – May 2021
• Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021
• Metastatic Cancer probably reduced by vitamin D - many studies
• Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019
• Radiation therapy, used to treat some cancers, causes less damage if use Vitamin D (or Melatonin) – Aug 2022
• Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
• Vitamin D prevents and treats cancer in many ways – May 2021
• Palliative care is helped by Vitamin D - many studies
• 4X less of one chemo needed after vitamin D receptor activation - June 2020

Breast Cancer

• Breast Cancer survivors with high vitamin D were 3.3 X less likely to have metastases – May 2023
• Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023
• Breast cancer recurred twice as often if have less than 20 ng of vitamin D – Dec 2018
• Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017

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Vitamin D in Cancer Prevention: Gaps in Current Knowledge and Room for Hope - Oct 2022

Nutrients 2022, 14(21), 4512; https://doi.org/10.3390/nu14214512
by Matthias Henn et. al
(This article belongs to the Special Issue The Role of Vitamin D in Cancer Prevention) - which includes

- - - - - - - - - - - - - -

Table of Contents

Intensive epigenome and transcriptome analyses have unveiled numerous biological mechanisms, including the regulation of cell differentiation, proliferation, and induced apoptosis in neoplastic cells, as well as the modulation of the antineoplastic action of the immune system, which plausibly explains the observed population-based relationship between low vitamin D status and increased cancer risk. However, large randomized clinical trials involving cholecalciferol supplementation have so far failed to show the potential of such interventions in cancer prevention. In this article, we attempt to reconcile the supposed contradiction of these findings by undertaking a thorough review of the literature, including an assessment of the limitations in the design, conduct, and analysis of the studies conducted thus far. We examine the long-standing dilemma of whether the beneficial effects of vitamin D levels increase significantly above a critical threshold or if the conjecture is valid that an increase in available cholecalciferol translates directly into an increase in calcitriol activity. In addition, we try to shed light on the high interindividual epigenetic and transcriptomic variability in response to cholecalciferol supplementation. Moreover, we critically review the standards of interpretation of the available study results and propose criteria that could allow us to reach sound conclusions in this field. Finally, we advocate for options tailored to individual vitamin D needs, combined with a comprehensive intervention that favors prevention through a healthy environment and responsible health behaviors.
 Download the PDF from VitaminDWiki

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See also VitaminDWiki

• Metastatic Cancer probably reduced by vitamin D - many studies
• Vitamin D prevents and treats cancer in many ways – May 2021
• Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022

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569,000 hits for search of: Cancer "vitamin d" (supplementation OR RCT OR trial)

Google Scholar Oct 2022)

• A randomized placebo-controlled trial of vitamin D supplementation for reduction of mortality and cancer: Statistical analysis plan for the D-Health Trial - June 2019 https://doi.org/10.1016/j.conctc.2019.100333 FREE PDF
• Vitamin D supplementation for prevention of cancer: The D2d cancer outcomes (D2dCA) study= June 2019 https://doi.org/10.1016/j.cct.2019.04.015 FREE PDF 4,000 IU -
• Effect of Vitamin D3 Supplements on Development of Advanced CancerA Secondary Analysis of the VITAL Randomized Clinical Trial - NOV 2020 https://doi.org/doi:10.1001/jamanetworkopen.2020.25850 FREE PDF
  • "In this randomized clinical trial, supplementation with vitamin D reduced the incidence of advanced (metastatic or fatal) cancer in the overall cohort, with the strongest risk reduction seen in individuals with normal weight."
  • see Metastatic Cancer probably reduced by vitamin D - many studies

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987+ VitaminDWiki pages have CANCER etc. in the title

CANCER OR LYMPHOMA OR LEUKEMIA OR MYLENOMA OR Osteosarcoma OR Adenocarcinoma
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