Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease - April 2018
J Med Food. 2018 Mar 22. doi: 10.1089/jmf.2017.0130. [Epub ahead of print]
Câmara AB1, de Souza ID1, Dalmolin RJS1,2.
1 Bioinformatics Multidisciplinary Environment, IMD, Federal University of Rio Grande do Norte , Natal, Brazil .
2 Department of Biochemistry, CB, Federal University of Rio Grande do Norte , Natal, Brazil .
More sun associated with less Alzheimer's
Alz death rate in 90 countries having life expectancy >75 years
LEFT: 55 countries with high sunshine; RIGHT: 35 countries with low sunshine.
- Does Less Sun mean More Disease 5 minute video by VitaminDWiki
- Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- Alzheimer’s patients are genetically 70 percent more likely to be vitamin D in-efficient – Feb 2012
- Alzheimer’s (apoE4) may require more than Omega-3 - May 2017
- Alzheimer’s and Vitamins D, B, C, E, as well as Omega-3, metals, etc. – June 2013
- Severe Alzheimer's delayed by 1 year with vitamin D intervention – March 2014
Types of evidence that Vitamin D helps brain problems - 2014
Overview Alzheimer's-Cognition and Vitamin D has the following summary
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
- It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home. $75/month.
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
There are 97+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+ studies
16+ studies in both categories Cognitive and Omega-3
Download the PDF from Sci-Hub via VitaminDWiki
How Vitamin D and its receptor protect against Alzheimer's
Vitamin D (VD) deficiency is a growing problem, affecting a significant portion of the population in many countries. VD deficiency may be related to several diseases, including Alzheimer's disease (AD). This study aimed to review the relationship between VD deficiency and AD.
We describe the proteins involved in AD pathogenesis and how those proteins can be influenced by VD deficiency. We also investigated a relationship between AD death rate and solar radiation and we found an increased AD death rate in countries with low sunlight.
It was also observed that amyloid precursor protein, ryanodine receptor, mammalian target of rapamycin complex 1, and receptor for advanced glycation end products are associated with a worse prognosis in AD. While the Klotho protein, phosphatase and tensin homologue, and VD receptor are associated with a better prognosis in the disease.
The literature suggests that decline in VD concentrations may be involved in the establishment and progression of AD. According to sunlight data, we can conclude that countries with low average sunlight have high AD death rate.
Alzheimer's increase is due to increased meat consumption - July 2016
Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer's Disease
J Am Coll Nutr. 2016 Jul;35(5):476-89. doi: 10.1080/07315724.2016.1161566.
Grant WB1.
TEACHING POINTS:
• Single-country ecological data can be used to find links between diet and AD because the national diet changes,
such as during the nutrition transition to a Western diet.
• Multicountry ecological studies can be used to find links between dietary factors and risk of AD.
• Prospective observational studies are useful in linking dietary components and patterns to risk of AD.
• The most important dietary link to AD appears to be meat consumption, with eggs and high-fat dairy also contributing.
• Diets high in grains, fruits, vegetables, and fish are associated with reduced risk of AD,
but these factors cannot counter the effects of meat, eggs, and high-fat dairy.
• Higher vitamin D status is associated with reduced risk of AD.
Rates of Alzheimer's disease (AD) are rising worldwide. The most important risk factors seem to be linked to diet. For example, when Japan made the nutrition transition from the traditional Japanese diet to the Western diet, AD rates rose from 1% in 1985 to 7% in 2008. Foods protective against AD include fruits, vegetables, grains, low-fat dairy products, legumes, and fish, whereas risk factors include meat, sweets, and high-fat dairy products.
The evidence comes from ecological and observational studies as well as investigations of the mechanisms whereby dietary factors affect risk.
The mechanisms linking dietary risk factors to AD are fairly well known and include
- increased oxidative stress from metal ions such as copper as well as from advanced glycation end products associated with high-temperature cooking
- increased homocysteine concentrations, and cholesterol and its effects on amyloid beta, insulin resistance, and obesity.
Lower 25-hydroxyvitamin D concentrations also are associated with increased risk of AD.
In addition to reviewing the journal literature, a new ecological study was conducted using AD prevalence from 10 countries
- (Brazil, Chile, Cuba, Egypt, India, Mongolia, Nigeria, Republic of Korea, Sri Lanka, and the United States)
along with dietary supply data 5, 10, and 15 years before the prevalence data. Dietary supply of meat or animal products less milk 5 years before AD prevalence had the highest correlations with AD prevalence in this study. Thus, reducing meat consumption could significantly reduce the risk of AD as well as of several cancers, diabetes mellitus type 2, stroke, and, likely, chronic kidney disease.
PMID: 27454859 DOI: 10.1080/07315724.2016.1161566
Download the PDF from Sci-Hub via VitaminDWiki
Alzheimers vs Meat Consumption
Table 4. Mechanisms to Explain Dietary Risk Factors for AD
Table 5. Evidence That Meat Consumption Is Causally Linked to Risk of AD
Using Hill’s Criteria for Causality in a Biological System