Vitamin D roles in obesity: genetics and cell signaling – June 2013

The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms.

Nutr J. 2013 Jun 25;12(1):89.
Vinh Qu C L Ng K, Nguy N LT.

The prevalence rates of overweight and obesity are considered an important public issue in the United States, and both of these conditions are increasing among both children and adults. There is evidence of aberrations in the vitamin D-endocrine system in obese subjects. Vitamin D deficiency is highly prevalent in patients with obesity, and many studies have demonstrated the significant effect of calcitriol on adipocytes.
Genetic studies have provided an opportunity to determine which proteins link vitamin D to obesity pathology, including the

• vitamin D receptor,
• toll-like receptors, the
• renin-angiotensin system,
• apolipoprotein E,
• vascular endothelial growth factor, and
• poly(ADP-ribose) polymerase-1.

Vitamin D also exerts its effect on obesity through cell-signaling mechanisms, including

• matrix metalloproteinases,
• mitogen-activated protein kinase pathways, the
• reduced form of nicotinamide adenine dinucleotide phosphate,
• prostaglandins,
• reactive oxygen species, and
• nitric oxide synthase.

In conclusion, vitamin D may have a role in obesity.
The best form of vitamin D for use in the obese individuals is calcitriol because it is the active form of the vitamin D3 metabolite,
its receptors are present in adipocytes, and modulates inflammatory cytokine expression.

PMID: 23800102

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See also VitaminDWiki

• Overview Obesity and Vitamin D
• Obese have 50 percent less of two enzymes in fatty tissue to process vitamin D – May 2013
• Vitamin D and Obesity – Review March 2013
• No apparent genetic association between vitamin D and obesity – Feb 2013
• Genes indicate that Obesity causes vitamin D deficiency – Feb 2013
• Trying to understand the effect of genetics vitamin D levels in the blood – Jan 2013
• Common Vitamin D gene variants and resulting diseases – Jan 2013
• All items in category Genetics 343 items

Items in both of the categories of Genetics AND Obesity