SSRI Drugs Can Cause Chronic Fatigue Syndrome - Mercola April 2024

---

SSRI Drugs Can Cause Chronic Fatigue Syndrome

Mercola April 2024

STORY AT-A-GLANCE

• SSRIs, which increase serotonin levels, have been linked to chronic fatigue syndrome (CFS). A study showed that administering Prozac (fluoxetine) to mice at high dosages induced symptoms of CFS, suggesting a link between excessive serotonin levels and the condition
• Symptom reversal was achieved with the serotonin inhibitor fenclonine
• Other serotonin inhibitors include Benadryl, the H2 blocker Pepcid (famotidine), aspirin, progesterone and GABA
• Branched-chain amino acids, tyrosine, phenylalanine and L-theanine can also help reduce serotonin levels
• GABA is a more effective solution for conditions typically treated with SSRIs, such as depression and anxiety, without the adverse effects associated with elevated serotonin
• Reducing intake of linoleic acid (LA), found in high amounts in seed oils and certain meats, is recommended if you have CFS, as excess LA impair your mitochondrial function and cellular energy production
  • Note: LAs reduces the Omage-3

 Download the PDF from VitaminDWiki

---

Some SSRIs (fluoxetine) inhibit CYP27A1, thus reducing Vitamin D

Perplexity AI April 2024
The specific SSRIs that have been noted to inhibit CYP27A1 include citalopram, fluoxetine, and sertraline17. This inhibition can lead to drug-drug interactions, particularly in patients who are on multiple medications, as CYP27A1 plays a role in the metabolism of various substances1417.

VitaminDWiki - Genetics chart shows the vitamin D genes

---

VitaminDWiki – Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013

---

VitaminDWiki – Depression contains

• Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
• Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
• Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses – Jan 2023
• Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023
• Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
• Depression treated by Omega-3 (again) – meta-analysis Aug 2019
• Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
• Omega-3, Magnesium, and St. Johns' Wort also decrease depression
  • Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
  • Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
• Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
• There are 268 items in the Depression category in VitaminDWiki

Some recent publications

• Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis June 2023
• Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
• Post-partum depression and low Vitamin D - many studies
• Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023

---

VitaminDWiki – Overview Fibromyalgia or Chronic Fatigue and vitamin D