Loading...
 
Toggle Health Problems and D

Response by obese to weekly 50,000 IU of Vitamin D – May 2018

IGF and IGFBP as an index for discrimination between vitamin D supplementation responders and nonresponders in overweight Saudi subjects.

Medicine (Baltimore). 2018 May;97(19):e0702. doi: 10.1097/MD.0000000000010702.
Al-Daghri NM1, Yakout SM1, Wani K1, Khattak MNK1, Garbis SD2, Chrousos GP3, Al-Attas OS1, Alokail MS1.

VitaminDWiki

200 Overweight Saudis, average age 40, with Vitamin D levels < 20 ng
3 sets of 8 weeks supplementation for each of the following

  1. 50,000 IU weekly
  2. 50,000 IU every-other week
  3. 1,000 IU daily

Total =608,000 IU = 400,000 IU + 200,000 IU + 8,000 IU
600,000 IU over 6 months
Note: Some overweight subjects experienced a DECREASE in Vitamin D blood levels
Probably due to not adjusting the resuts for seasonal change which is typical in most people


See also VitaminDWiki

 Download the PDF from VitaminDWiki

Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like growth factor (IGF) and insulin growth factor binding protein (IGFBP) with serum 25(OH)D in response to vitamin D supplementation in a Saudi population. A total of 199 (89 males/110 females) vitamin D deficient subjects (25(OH)D level <50 nmol/L), aged 40.4 ± 11.4 years, were given vitamin D supplements (50,000 IU/mL every week) for the first 2 months, then twice a month for 2 months, followed by daily 1000 IU in the last 2 months. Fasting blood samples were taken at baseline and 6 months after the final dose of vitamin D. Serum 25(OH)D, IGF-1 and IGF-2, and IGFBPs 2-5 were measured. Vitamin D response was computed for all subjects as the difference in levels of serum 25(OH)D concentration at the end of 6 months compared to baseline. After intervention, serum 25(OH)D concentration significantly increased from 35.6 nmol/L (26.6-43.5) to 61.8 nmol/L (54.8-73.3) in responder subjects (P < .01) and from 35.1 nmol/L (21.2-58.2) to 38.3 nmol/L (25.5-48.3) in nonresponders (P = .13). Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes. IGF1 and IGF-1/IGFBP-3 ratio significantly increased in all subjects after 6 months (P = .01). Changes in 25(OH)D was significantly associated with changes in IGFBP-2 and IGF-1/IGFBP-3 ratio in responders only. This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction. Moreover, increase in serum 25(OH)D and IGF-I/IGFBP-3 molar ratio are more sensitive markers for the response to vitamin D supplementation in Saudi population.

Title revision of Feb 2020 caused the visitor count to reset.
There have actually been 5498 visitors to this page since it was originally made


Created by admin. Last Modification: Wednesday February 12, 2020 00:09:35 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
9834 IGF Vit D response in Obese.pdf admin 10 May, 2018 233.83 Kb 629