Vitamin D Deficiency Increases the Risk of Adverse Neonatal Outcomes in Gestational Diabetes.
PLoS One. 2016 Oct 20;11(10):e0164999. doi: 10.1371/journal.pone.0164999. eCollection 2016.
Weinert LS1, Reichelt AJ2, Schmitt LR3, Boff R1, Oppermann ML4, Camargo JL1,2, Silveiro SP1,2.
Gestational Diabetes has been proven to be treated by Vitamin D
Pages listed in BOTH the categories Diabetes and Pregnancy
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- Diabetes 30% more likely in those with low birth weight - June 2023
- Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022
- Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
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- Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017
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- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
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- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
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- Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016
- T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
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- Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015
- Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013
- Vitamin D protects against many types of health problems – review May 2013
- Dr. Holick video on vitamin D - March 2013
- Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
Download the PDF from VitaminDWiki
BACKGROUND:
Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM.
METHODS:
184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement. Vitamin D was measured by chemiluminescence and deficiency was defined as < 20 ng/mL. Participants were followed until puerperium and adverse neonatal outcomes were evaluated.
RESULTS:
Newborns of women with vitamin D deficiency had higher incidences of
- hospitalization in intensive care units (ICU) (32 vs 19%, P = 0.048), of
- hypoglycemia (any, 17.3 vs 7.1%, P = 0.039
- requiring ICU, 15.3 vs 3.6%, P = 0.008), and were
- more frequently small for gestational age (SGA) (17.3 vs 5.9%, P = 0.017).
After adjustment, relative risk (RR) for
- hypoglycemia requiring ICU was 3.63 (95%CI 1.09-12.11) and for
- SGA was 4.32 (95%CI 1.75-10.66).
The incidence of prematurity, jaundice and shoulder dystocia was no statistically different between groups.
CONCLUSIONS:
In this cohort of pregnant women with GDM, vitamin D deficiency was associated with a major increase in the incidence of adverse neonatal outcomes such as SGA newborns and neonatal hypoglycemia.
PMID: 27764194 PMCID: PMC5072629 DOI: 10.1371/journal.pone.0164999