Long-term clinical and biochemical residue after COVID-19 recovery
Egyptian Liver Journal volume 11, https://doi.org/10.1186/s43066-021-00144-1
Mohammed Ali Gameil, Rehab Elsayed Marzouk, Ahmed Hassan Elsebaie & Salah Eldeen Rozaik
Blood measured 3 to 6+ months after PCR positive test
Healthy vs months after COVID-19 Recovery
This very interesting study does not show
1) Levels in persons BEFORE COVID
2) Levels in people with Long-Haul
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Background
The long-term health consequences of coronavirus disease 2019 (COVID-19) are still unclear. The majority of previous trials addressed the post-COVID-19 symptoms through comprehensive medical questionnaires for relatively short periods after recovery. We tried to detect the potential pathological clinical signs and biochemical residue which persist for more than 3 months after the negative real-time polymerase chain reaction (RT-PCR) test of SARS-CoV-2.
Results
Among 120 COVID-19 survivors of mean age 38.29 and 55.6% male proportion,
- systolic blood pressure was significantly elevated (P=0.001).
- Erythrocyte sedimentation rate (ESR),
(C-reactive protein (CRP),
- D-dimer showed higher values in COVID-19 survivors (P< 0.001).
- Alanine aminotransferase (ALT),
- aspartate aminotransferase (AST),
- gamma-glutamyl trans-peptidase (GGT), and
- alkaline phosphatase (ALP) were significantly elevated in contrast to
- serum albumin that was reduced in COVID-19 survivors (P ≤0.001).
- Serum lipase,
- amylase and
- albuminuria
were higher in COVID-19 survivors (P ≤0.001).
Regression analysis (AOR, 95% CI) showed that ESR (P = 0.014), haemoglobin concentration (P = 0.039), serum lipase (P= 0.018), blood urea nitrogen (P= 0.003), albuminuria (P= 0.046), 25(OH) vitamin D (P= 0.002), and serum uric acid (P= 0.005) were the significant predictors of COVID-19 survivors (94.8% an overall prediction).
Conclusion
COVID-19 survivors experienced residual significant clinical and biochemical alterations that necessitate comprehensive medical care and close follow-up for longer periods.